0529 Flashcards

(49 cards)

1
Q

imperforate anus is most commonly assoc with?

A
GU tract malformations-
renal agenesis,
hypospadias,
epispadias, 
bladder extrophy
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2
Q

striate of occipital lobe

A

= primary visual cortex.

cuneus gyrus: lower visual field.
lingual gyrus: upper visual field.

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3
Q

physio changes in dilated cardiomyopathy

A

ventricular dilatation.
contractile (systolic) dysfunction.
S&S of CHF.

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4
Q

when does diastolic dysfunction occur?

A

when there is impaired LV filling due to reduced LV compliance.

ex: hypertensive heart disease.
restrictive CM.
hypertrophic CM.

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5
Q

most common heart sx in SLE

A

pericarditis-

chest pain radiating to neck and shoulders, relieved by sitting up.

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6
Q

result of high altitude for several days

A

hypoxemia with chronic resp alkalosis

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7
Q

long term sequelae of hydrocephalus in early infancy

A

lower extremity spasticity, muscle hypertonicity and hyperreflexia due to stretching of periventricular pyramidal tracts.

also:
visual disturbances.
learning disabilities.

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8
Q

chronic lymphedema

A

may be due to axillary LN dissection.

predisposes to cutaneous angiosarcoma (Stewart-Treves syndrome).

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9
Q

NNRTI (non-nucleoside reverse transciptase inhibitors)

A

nevirapine, efavirenz, delavirdine.

do not require activation by intracellular phosphorylation.

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10
Q

pseudomonas features

A
Gm neg rod.
motile.
aerobic.
non lactose-fermenting.
oxidase positive.
pyocyanin pigment.
grape/fruity odor.
endotoxin (fever, shock).
exotoxin A (inactivate EF-2).
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11
Q

arteriovenous conc gradient in anesthetics

A

reflects solubility of anesthetic in tissues.

HIGHER gradient = more soluble = high tissue uptake = slower onset of action.

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12
Q

most potent class of diuretics

A

LOOP-

used for edema in various settings (pulmo, CHF, peripheral)

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13
Q

third part of duodenum is closely assoc with?

A

uncinate process of pancreas and SMA

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14
Q

SMA syndrome

A

transverse portion of duo is entrapped btn SMA and aorta, causing sx of partial intestinal obstruction

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15
Q

what happens when antidepressants are used in the depressed phase of bipolar d/o?

A

rapid switch to mania

*need to use with antipsychotic or mood stabilizer

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16
Q

where does parvovirus B19 replicate?

A

bone marrow (tropic for erythroid precursor cells, esp pronormoblasts and normoblasts)

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17
Q

nitrogen atoms of urea molecule are derived from?

A

NH3 and aspartate

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18
Q

rate-limiting enzyme of urea cycle?

A

carbamoyl phosphate synthetase I.

activated by N-acetylglutamate (NAG).

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19
Q

how is Listeria eliminated from body?

A

cell-mediated immunity (neonates and immunocompromised are vulnerable)

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20
Q

hemolysis by Listeria

A

very narrow zone of beta-hemolysis on sheep blood agar (similar to beta-hemolytic strep)

21
Q

stasis dermatitis

A

due to chronic venous insuff (in varicose veins).

erythema and scaling with progressive dermal fibrosis and hyper pigmentation.

22
Q

lipoprotein lipase deficiency

A

results in increased conc of serum chylomicrons which contain triglycerides.

high serum TG (above 1000 mg/dL) = risk of acute pancreatitis.

23
Q

how do cholinergic agonists affect endo cells?

A

bind muscarinic receptors.

promote release of NO (EDRF), which activates guanylate cyclase and diminishes endo calcium conc to cause VASODILATION.

24
Q

thalamic syndrome

A

total sensory loss on contra side of body.

NO MOTOR DEFICITS but proprioception problems may lead to trouble walking and falling.

25
tetrahydrobiopterin (BH4)
cofactor for tyrosine, DOPA, serotonin, and nitric oxide synthesis
26
atypical PKU
deficient dihydrobiopterin reductase = deficiency of BH4
27
how does diphtheria toxoid prevent disease?
stimulate neutralizing Ab prod (IgG) against B subunit of exotoxin- prevents Binding to host cell membrane receptors
28
presentation of constrictive pericarditis
slowly prog dyspnea. peripheral edema. ascites.
29
narcolepsy TX
scheduled daytime naps | + psychostimulants (modafinil)
30
early-onset pericarditis post-MI
days 2-4. inflamm rxn to transmural cardiac muscle necrosis that occurs in adjacent visceral and parietal pericardium. TX: aspirin.
31
late-onset pericarditis post-MI
1 wk-months later. DRESSLER's SYNDROME. autoimmune.
32
GABA rxns
synth from glutamate via glutamate decarboxylase. catabolized by transamination via GABA transaminase. *BOTH rxns use B6
33
GABA-A receptor binds what?
benzodiazepines. barbiturates. alcohol. zolpidem. *all have diff binding sites (except benzos and zolpidem)
34
GABA-B differs from other GABA receptors in that?
it is linked to G-protein. GABA-A and -C are ion channels.
35
sotalol
class 3 anti arrhythmic. 1. beta blocking abilities: cause mild bradycardia. 2. K channel blocking abilities: cause QT prolongation.
36
recurrent lobar hemorrhages
due to cerebral amyloid angiopathy. | more benign than HTN hemorrhagic strokes.
37
how do beta blockers affect renin?
inhibit renin release by blocking beta 1 receptor on JG cells
38
where are beta 1 receptors found?
cardiac tissue and renal JG cells- | increase cAMP levels
39
chronic thiamine (B1) deficiency leads to diminished ability of cerebral cells to?
use glucose- | due to decreased function of enzymes that need B1 cofactor (PDH, alphaKG DH, transketolase)
40
what enzyme is elevated in thiamine deficiency and is thus diagnostic?
erythrocyte transketolase
41
valproate in pregnancy
increased risk of NTDs (valproate inhibits intestinal folic acid absorption)
42
cardiovascular dysphagia
due to dilated LA putting pressure on esophagus. LA enlarged due to mitral stenosis or LV failure.
43
very high levels of hCG can cause...?
hyperthyroidism- stimulate TSH receptors
44
what helps clotting in hemophilia?
addition of thrombin to pt's blood (pt cannot convert prothrombin to thrombin)
45
N-acetylcysteine in CF
mucolytic. | cleaves disulfide bonds within mucus glycoproteins to loosen thick sputum.
46
vit A overdose
``` intracranial HTN (papilledema). skin changes. hepatosplenomegaly. ```
47
lymphogranuloma venerum
chlamydia trachomatis L1-3. painless ulcers that progress to painful inguinal lymphadenopathy and ulceration. chlamydial inclusion bodies in cytoplasm.
48
Hib virulence relies on?
PRP capsule- | prevents phago and intracellular killing by neutrophils
49
unencapsulated H.influenzae strains cause?
local infxs only- sinusitis, bronchitis, otitis media | part of normal flora