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004 - Parasitology > 05 - Hemoflagellates > Flashcards

05 - Hemoflagellates Flashcards

1
Q

You’ve found Trypanosoma Cruzi! the cause of what?

A

Chagas Disease or American trypanosomiasis

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2
Q

(Hemoflagellates)

(Heteroxeonus)

  1. different + strangers
  2. a parasite that has what?

(Vertebrates)

  1. bloo, also tissue fluids and cells
  2. bloodsucking incsects
A
  1. more than one obligatory host in its life cycle
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3
Q

(Characteristics)

  1. flagellum?
  2. kinetoplast

is a large mitochondrian

adjacent to what?

  1. undulating membrane
A
  1. basal body
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4
Q

pathogenic are the important one - nt that you really need to memorize them or anything

A
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5
Q

(Trapanosoma Cruzi)

  1. American trypanosomiasis (aka what?)
A
  1. Chagas disease
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6
Q

(Trypanosoma Cruzi)

(Hosts)

(definitive hosts)

  1. what are they?

(reservoir hosts)

  1. ?

(intermediate hosts)

  1. ?
A
  1. humans, dogs, primates
  2. armadillos, cats, chickens, rodents, bats, pigs, marsupials (possums)
  3. kissing bugs

vectors triatoma, rhodnius, panstrongylus

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7
Q

(Trypanosoma Cruzi)

A

so only 12 species are actually vectors

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8
Q
A

should figure this out… when it feeds it defecates - therefore dropping bacteria into bite site

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9
Q

(Transmission of T. Cruzi to Humans and Dogs)

  1. What is the most significant route?
A
  1. trypanosome-infected bug feces rubbed into bite wound or intact mucous membranes

(Other: blood transfusion, ingestion of infected meat, congenital transmission)

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10
Q

(Chagas Disease)

  1. Acute and chronic phase of what?
A
  1. American trypanosomiasis
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11
Q

(Chagas Disease)

(Chagoma)

HE WILL NOT ASK ABOUT HUMAN SIGNS

  1. local swelling where?
  2. then what?

(Romana’s sign)

  1. chagoma
  2. unilateral conjuctivitis with twhat?
A
  1. at site of trypanosome entry
  2. parasite multiplication
  3. orbital edema
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12
Q

(Chagas Disease)

(Chronic Phase)

  1. Clincial disease reappears how many years after infection?

he said he won’t ask about human signs so just take a look

A
  1. 10 to 20 years
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13
Q
A
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14
Q

(Canine Chagas Disease)

  1. acute signs?
  2. chronic?
A
  1. fever, lymphadenopathy, diarrhea, myocarditis (arrhythmias, death)
  2. 8 to 26 months post-infection

dilated cardiomyopathy

ventricular arrhtmias

R-CHF

(dogs do go chronic all that often - he sounded like only know acute)

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15
Q

(Canine Chagas Disease)

A
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16
Q

(Canine Chagas Disease)

(treatment)

  1. kill what?
  2. with what?
  3. drugs available for chronic stage?
A
  1. circulating trypomastigotes
  2. nifurtimox, benznidazle, allopurinol
  3. no
17
Q
A
18
Q

he said we will find nagana on an exam at some point for sure

A
19
Q

(African Trypanosomiasis)

  1. transmitted by what?
A
  1. tsetse flies (flossina spp.)
20
Q
A
21
Q

(African Trypanosomiasis)

(Nagana)

  1. What are hosts?
A
  1. antelopes and other native ruminants

(also cattle, sheep, goats, pigs, horses, camels, dogs, and cats)

22
Q

(African Trypanosomiasis)

A
23
Q

(African Trypanosomiasis)

(Disease)

  1. Severity of disease depends on what?
  2. Mortality associated with level of…
A
  1. trypanosome spp. and host susceptibiliity
24
Q
A
25
Q

(Other trypanosomes)

(T. evansi)

  1. “Surra”
  2. affects what?
  3. Asia, C & S, America
  4. transmitted by what?
  5. disease similar to what?
A
  1. horses, camels, deer, other mammals
  2. tabanid and stable flies
  3. T. brucei
26
Q

(Other trypanosomes)

(T. Equiperdum)

  1. dourine, mal du coit
  2. Venereal disease of what?
  3. Asia, Eastern Europe, Africa
  4. Eradicated in US and W Europe

(Three stages)

1-3. what are they?

  1. can it be fatal?
  2. Drug treatment can result in what?
A
  1. horses and donkeys
  2. edema, discharge, depigmenation of penis or vulva
  3. rash on sides of body
  4. paralysis (neck and nostrils, then hind, then rest of body)
  5. yes (unless treated)
  6. inapparent carriers (suamin, diminazene, qiapryamine, cymelarsan

004 - Parasitology (13 decks)

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