04 - neoplasia

Question 1

1. once inflammation ruled out - morph deviations assumed NOT to be assoc with inflammation -> then one must decide if weird looking cells are benign or malignant

Question 2

(mesenchymal: fibroblasts, osteoblasts, chondroblasts)
1. how easily do they exfoliate?
2. shape?
3. form organized sheets of cells?
4. can the criteria of malignancy be applied to determine cellular disposition?

Answer 2

1. poorly
2. ovoid, stellate, fusiform, spindled, elongate
3. never (will form disorganized clumps)
4. yes

Question 3

(epithelial: squamous cells, GI mucosa, hepatocytes, renal tubular cells)
1. exfoliate well?
2. shape?
3. form cohesive sheets?
4. can criteria of malignancy be applied?

Answer 3

1. yes
2. roundish/polygonal (can be spindle shaped though…)
3. yep (and disorganized clumps)

can be acinar if glandular epi

4. no

Question 4

(round or discrete)

1. exfoliate well?
2. shape?
3. form cohesive sheets?

Answer 4

1. extremely well
2. round with round nucleus
3. NEVER

Question 5

(round or discrete)

(lymphocytes)

1. are immature cells smaller or larger?
2. what is the main feature used to determine malignancy, regardless of location?
3. what type of lymphoma is impossible to dx cytologically?
4. interpretation very difficult w/o biopsy

Answer 5

1. larger
2. the population

more pure (esp young) -> more malignant

3. small cell lymphoma

Question 6

(round or discrete)

(transmissible venereal tumor)

Question 7

(round or discrete)

(plasma cells)

Question 8

(round or discrete)

(benign cutaneous histiocytoma)

Question 9

(round or discrete)

(mast cell tumor)

1. well-differentiated mast cells have abundant, small, dark purple granules that often obscure the round nucleus

Question 10

(round or discrete)