02 - inflammation

Question 1

1. the first thing any diagnostic sample should be evaluated for is inflammation.

inflammation can induce a variety of hyperplastic, dysplastic, and metaplastic changes in the noninflammatory components of a smear

these changes could be misinterpreted as neoplastic changes

by ruling out inflammation, the background, other populations present, and their morphologies can be then evaluated with confidence that the changes seen are a spontaneous change and not induced by inflammation

Question 2

1. what are these?
2. distinguishing features?

Answer 2

1. neutrophils
2. segmented nuclei (not present in all)

Question 3

(from a dog)

1. lower left?
2. short arrow?
3. long arrow?

Answer 3

1. neutrophil
2. metamyelocyte (immature neutrophil)
3. monocyte (not the darker cytoplasm)

Question 4

1. what are these?
2. distinguishing feature?

Answer 4

1. eosinophils
2. orange granules

Question 5

1. what are these?
2. distinguishing features?

Answer 5

1. basophils
2. small, round, dark purple granules

canine have a “ribbon-like” nucleus

Question 6

1. what are these?
2. distinguishing features?

Answer 6

1. lymphocytes
2. dense chromatin and a small rim of light blue cytoplasm

Question 7

1. what are these?
2. how species specific?
3. distinguishing features?

Answer 7

1. monocytes
2. not - any of these could be present in any species…
3. vacuoles (not seen in all)

Question 8

(neutrophils)

1. what do females get that look like a drumstick on the end of a nuclear lobe?
2. what color is cytoplasm?

Answer 8

1. barr body
2. clear

Question 9

1. what is this?
2. distinguishing feature?

Answer 9

1. plasma cells
2. eccentrically placed nucles, dark blue cytoplasm due to lots of RER