02.20 Peripheral Arterial Occlusive Disease Flashcards
Atherosclerotic occlusive disease of the arterial system distal to the aortic bifurcation
PAD
Atherosclerosis commonly occurs in:
Aortic cusps
Branches of the aorta (subclavian and carotid)
Bifurcations (aorta to iliac artery, iliac artery to the superficial and deep femoral, anterior tibial to peroneal and posterior tibial artery, lumbar and iliac arteries
Progression of atherosclerosis
Initial lesion Fatty streak Intermediate lesion forms Atheroma develops Fibroatheroma Complicated lesion
Histologically normal
Macrophage infiltration in sites of inflammation
Isolated foam cells
Inital lesion
Intima of the vessel becomes thickened because of intracellular lipid accumulation
Fatty streak
Due to intracellular lipid accumulation and small extracellular lipid pools
Intermediate lesion forms
Mixture of lipid intracellular accumulations core of extracellular lipid
Stage where disease may already become overt, presenting with clinical symptoms
Atheroma develops
Fibrotic or calcific layers
Fibroatheroma
Because the intima is no longer smooth, there are hematoma-hemorrhages and some degree of thrombosis
Complicated lesion
How lesions cause symptom
Stenosis/occlusion
Embolism
Symptoms appear if _____
Collateral circulation is poor
Artery occludes acutely
Leg attack
pain is felt in large muscle groups distal to an arterial lesion after exercise
Intermittent claudication
Severe compromise of arterial flow
Failure of compensatory mechanisms
Exacerbated by elevation
Limb threatening
Ischemic rest pain
Tissue necrosis occurs when blood flow is inadequate to maintain tissue viability even at rest
Gangrene
RF for atherosclerosis
Tobacco use Diet DM Hyperlipidemia HPN Fam Hx
Important things to elicit in Hx
Cardiopulmonary assessment
Neurological assessment
Renal assessment
Specific vascular evaluation
Inspection of skin changes Capillary refill Auscultate for bruits in central vessels Pulse examination Pulse grading
Absence of pulse
0/4
Weak (may suggest impairment)
Effort must be made to search for the pulse
1/4
Normal
2/4
Full
3/4
Bounding (may suggest aneurysm or calcification)
4/4