הצטברויות

Question 1

What are Russell Bodies?

Answer 1

Large eosinophilic intracellular inclusions containing antibodies found in plasma cells. the Russell body is characteristic of the distended endoplasmic reticulum

Question 2

איזו שיטת צביעה היא היחידה שמאפשרת לראות שינוי היאליני?

Answer 2

H&E

שינוי היאליני מבטא עודף חלבון ובד”כ מופיע בין התאים. נצבע בוורוד בוהק. קורה בסכרת, בד”כ בכליה.

Question 3

Amyloids:

• What are they?
• Where you can find them?
• What staining method is used?

Answer 3

• Aggregates of proteins. fibrillar morphology.
• Found in kidneys (especially in glomeruli), Heart, and other organs.
• Kongo-Red, Green polarizing lens.

Question 4

Amyloidosis:

Answer 4

• Amyloidosis is abnormal protein deposits primarily in the extracellular space, and it is a characteristic of some disorders associated with the liver, kidneys, heart, and other tissues.

Question 5

Mallory Bodies are:

Answer 5

• Keratin fibrillar deposits in hepatocytes.
• associated with alcoholism.
• Reversible.

Question 6

Niemann-Pick diseases are:

Answer 6

• involve the dysfunctional metabolism of sphingolipids, which are fats found in cell membranes (so it is a kind of sphingolipidosis, which is included in the larger family of lysosomal storage diseases)
• NPC (type C) is due to mutation of an enzyme involved in cholesterol catabolism.

Question 7

What staining techniques used to examine steatosis?

Answer 7

• Oil red
• Sudan Black
  The slides are needed to be frozen!

Question 8

What are the causes for protein aggregation?

Answer 8

• Excessive Synthesis
• Misfolding
• Absorption (reabsorption)
• Defects in transport.

Question 9

Prussian Blue staining is used to dye:

Answer 9

• iron. (Fe)

Question 10

Hemosiderin granules form when…

Answer 10

• There is local/systemic excess ferritin micelles.

- Hemosiderin pigment (yellow to brown) represents aggregates of ferritin micelles.

Question 11

Hemosiderosis is a condition when there is a systemic overload of iron and hemosiderin may be deposited in many organs or tissues. what are the main causes for this situation?

Answer 11

1. Genetic disorder called Hemochromatosis - increased absorption of dietary iron.
2. Hemolytic anemia
3. Repeated blood transfusions.

Question 12

Psammoma bodies, what are they?

Answer 12

Calcium-Salts accumulation.