Zoonotics: Bartonella Henselae (Gram Neg Bacilli Bacteria)

Question 1

Causes Disease

Cat Scratch Fever?

Answer 1

• Bartonella Henselae*
• ———————————-*
• causes ?*

Question 2

Bartonella Henselae

Morphology:

Answer 2

Gram Neg. Bacilli/Rod Bacteria

Pleomorphic

Question 3

Bartonella Henselae

STAIN REQUIRED?

Answer 3

Special Stain required:

Wartharin Starry (Silver) Stain

Question 4

Bartonella Henselae

causes 2 diseases:

NAME:

Answer 4

• 1. Cat scratch Fever*
• 2. Bacillary angiomatosis*

Question 5

Cat scratch fever

is caused by what organism?

Name Transmission:

Answer 5

Bartonella Henselae

1. Cat

Question 6

Bacillary Angiomatosis

is caused by what organism?

Name Transmission:

Answer 6

• Bartonella Henselae*
• 1. Cat scratch*

Question 7

Bartonella Henselae

Causes what type of Disease involving

Immunocompromised Individuals?

S/S?

Answer 7

Bacillary Angiomatosis

S/S

-Occurs in “Immunocompromised “ individuals

• • Fever - Chills*
• Headaches*

Raised Red Vascular Lesions (all over Body-skin)

HIV infected Pt’s

Question 8

Cat scratch Disease Fever

is caused by what organism?

S/S?

Answer 8

Bartonella Henselae

S/S:

1. Fever
2. Reginal Lymph nodes (axilla)

occurs in immunocopetant individuals

3. Painful Lymph nodes (one arm/same side of scratch) Axilla Lymphadenitis

Question 9

Bartonella Henselae

Differential Diagnosis (similar)

Occurs in what type of individuals?

Answer 9

-Karposis Sarcoma

-Immunocompromised Individuals

Question 10

Karposis Sarcoma

Define:

Answer 10

- a type of cancer that can form masses in the skin, lymph nodes, or other organs.

• -The skin lesions are usually purple in color.*
• -They can occur singularly, in a limited area, or be widespread.*
• -It may worsen either gradually or quickly.*
• -Lesions may be flat or raised.*
• -Human herpesvirus 8 (HHV8) is found in the lesions of all those who are affected*
• -Risk factors include poor immune function, either as a result of disease or specific medications, and chronic lymphedema*

Question 11

Bartonella Henselae

TX: for

Bacillary Angiomatosis

Answer 11

TX:

Doxycycline

Macrolides (used for Cat scratch fever also)

Question 12

• Bartonella Henselae*
• TX: for*

Cat Scratch Fever

Answer 12

Self limiting

-if swelling of lymph nodes is painful and become unmanageable THEN TX with

Azythromycin

(lymphadenitis)

note: otherwise do not use !

Question 13

Bartonella Henselae

Complications:

Answer 13

• Endocarditis*
• Encephalitis*

Question 14

Bartonella Henselae

Labs:

Answer 14

Special Stain necessary for Biopsy visualization:

• Warthoarin Starry Silver Stain
• Serology
• Blood

Question 15

Bartonella Henselae

S/S visual ?

Answer 15

• -Papule* or Pustule at the incoulation site
• Tender
• Enlarged lymph nodes (usually on the same side of scratch)

Question 16

Lymphadenitis

Lymph:

aden:

itis:

Answer 16

• fluid
• iron
• inflammation

Axillary Lymphadenitis

Question 17

Endocoarditis:

Answer 17

• -Endocarditis is an infection of the endocardium, which is the inner lining of your heart chambers and heart valves.*
• -Endocarditis generally occurs when bacteria, fungi or other germs from another part of your body, such as your mouth, spread through your bloodstream and attach to damaged areas in your heart*

endocarditis can damage or destroy your heart valves and can lead to life-threatening complications

Question 18

Encephalitis :

Answer 18

• inflammation of the brain.
• most common is viral infection.
• Encephalitis often causes only mild flu-like signs and symptoms — such as a fever or headache inflammation of the brain.
• Encephalitis can also cause confused thinking, seizures, or problems with senses or movement

Question 19

Karposis Sarcoma

• Define:*
• Pt with this disease can develop what?*

Answer 19

Rare slow growing skin tumor

• usually males of Italian/E Europ. Jewish ancestry
• Pt’s with this Disease DEVELOP

“non-Hodgkin Lymphoma”

(blood cancers that include all kinds of cancers with exception of Hodghin’s lymphoma)

-develops in HIV patients

Question 20

Bartonella Henselae

Virulence Factor:

Answer 20

1. Adherence

2. TAA’s (Trimaric Antotransporter Adhesins)

3. LPS (lipopolysaccharide)

• also known as endotoxins,*
• -are large molecules consisting of a lipid and a polysaccharide composed of O-antigen,*
• -outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.*