Zoonotics: Bartonella Henselae (Gram Neg Bacilli Bacteria) Flashcards
Causes Disease
Cat Scratch Fever?
- Bartonella Henselae*
- ———————————-*
- causes ?*
Bartonella Henselae
Morphology:
Gram Neg. Bacilli/Rod Bacteria
Pleomorphic
Bartonella Henselae
STAIN REQUIRED?
Special Stain required:
Wartharin Starry (Silver) Stain
Bartonella Henselae
causes 2 diseases:
NAME:
- Cat scratch Fever*
- Bacillary angiomatosis*
Cat scratch fever
is caused by what organism?
Name Transmission:
Bartonella Henselae
1. Cat
Bacillary Angiomatosis
is caused by what organism?
Name Transmission:
- Bartonella Henselae*
- Cat scratch*
Bartonella Henselae
Causes what type of Disease involving
Immunocompromised Individuals?
S/S?
Bacillary Angiomatosis
S/S
-Occurs in “Immunocompromised “ individuals
- Fever - Chills*
- Headaches*
Raised Red Vascular Lesions (all over Body-skin)
HIV infected Pt’s
Cat scratch Disease Fever
is caused by what organism?
S/S?
Bartonella Henselae
S/S:
- Fever
- Reginal Lymph nodes (axilla)
occurs in immunocopetant individuals
- Painful Lymph nodes (one arm/same side of scratch) Axilla Lymphadenitis
Bartonella Henselae
Differential Diagnosis (similar)
Occurs in what type of individuals?
-Karposis Sarcoma
-Immunocompromised Individuals
Karposis Sarcoma
Define:
- a type of cancer that can form masses in the skin, lymph nodes, or other organs.
- -The skin lesions are usually purple in color.*
- -They can occur singularly, in a limited area, or be widespread.*
- -It may worsen either gradually or quickly.*
- -Lesions may be flat or raised.*
- -Human herpesvirus 8 (HHV8) is found in the lesions of all those who are affected*
- -Risk factors include poor immune function, either as a result of disease or specific medications, and chronic lymphedema*
Bartonella Henselae
TX: for
Bacillary Angiomatosis
TX:
Doxycycline
Macrolides (used for Cat scratch fever also)
- Bartonella Henselae*
- TX: for*
Cat Scratch Fever
Self limiting
-if swelling of lymph nodes is painful and become unmanageable THEN TX with
Azythromycin
(lymphadenitis)
note: otherwise do not use !
Bartonella Henselae
Complications:
- Endocarditis*
- Encephalitis*
Bartonella Henselae
Labs:
Special Stain necessary for Biopsy visualization:
- Warthoarin Starry Silver Stain
- Serology
- Blood
Bartonella Henselae
S/S visual ?
- -Papule* or Pustule at the incoulation site
- Tender
- Enlarged lymph nodes (usually on the same side of scratch)
Lymphadenitis
Lymph:
aden:
itis:
- fluid
- iron
- inflammation
Axillary Lymphadenitis
Endocoarditis:
- -Endocarditis is an infection of the endocardium, which is the inner lining of your heart chambers and heart valves.*
- -Endocarditis generally occurs when bacteria, fungi or other germs from another part of your body, such as your mouth, spread through your bloodstream and attach to damaged areas in your heart*
endocarditis can damage or destroy your heart valves and can lead to life-threatening complications
Encephalitis :
- inflammation of the brain.
- most common is viral infection.
- Encephalitis often causes only mild flu-like signs and symptoms — such as a fever or headache inflammation of the brain.
- Encephalitis can also cause confused thinking, seizures, or problems with senses or movement
Karposis Sarcoma
- Define:*
- Pt with this disease can develop what?*
Rare slow growing skin tumor
- usually males of Italian/E Europ. Jewish ancestry
- Pt’s with this Disease DEVELOP
“non-Hodgkin Lymphoma”
(blood cancers that include all kinds of cancers with exception of Hodghin’s lymphoma)
-develops in HIV patients
Bartonella Henselae
Virulence Factor:
1. Adherence
2. TAA’s (Trimaric Antotransporter Adhesins)
3. LPS (lipopolysaccharide)
- also known as endotoxins,*
- -are large molecules consisting of a lipid and a polysaccharide composed of O-antigen,*
- -outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.*
