ZOONOTIC EXOTIC DISEASES Flashcards
Dx of animals w/c are not and no longer present in country based on the classificatioon of OIE listings of diseases, A and B.
exotic diseases
neurological disorder affecting cattle
mad cow dz
BOVINE SPONGIFORM ENCEPHALOPATHY
misfolded proteins
○ Abnormal conformation of proteins
○ Non-living organisms
prions
Creutzfeldt-Jacobson syndrome
BSE
first detected sa dz na to na CS
san nadiagnose una tong dz na to
ano CFR
kelan nnakiikiita CS ng dz na to
scrapie
BSE - UK europe
100%
mature. 2-8 yrs
Foodborne exposure to prions
- Ingestion (Classical BSE)
- Associated with meat and bone meal
- Meat products from slaugther houses
- Have come frome infected animals
BSE
what form of BSE:
Cannot be associated with foodborne
- Basta sa old animals
- Natural occuring type of BSE in older
animals
atypical
After ingestion, prions replicate in __________
peyer’s patches
Purple circular areas = villi = intestines
dz where u need to be Extra precautions in performing necropsy
BSE
- Loss of body condition
- Behavior - reluctance to move, go from
one area to other - Reluctant to be milked
- Decrease milk yield
- Stares at the wall
- Hyperesthesia
- Inc sensitivity to touch and sound
- Changes in temperament
- Becomes aggressive
- Hindlimb ataxia
- If downer cow = cull
BSE
clinincal exam pang bSE
bang flash clipboard stick
what part of the brain ang sinusubmit sa histopath pag BSE
spongiform: intracytoplasmic Vacuolation in neurons ____
brainstem
grey matter
gold standard nng BSE
tx for BSE
Immunohistochemistry
no tx! high risk animals should NNOT be consumed like downner cows
Also known chlamydophila abortion ovine enzootic abortion
caused by:???
main source?
Transmission
OVINE ENZOOTIC ABORTION OR ENZOOTIC
ABORTION OF EWES
Chlamydophila abortus
birthing fluid and placenta vaginal
discharge, placenta and aborted fetus
Ingestion organisms - aerosols
Zoonotic implications ng OVINE ENZOOTIC ABORTION OR ENZOOTIC
ABORTION OF EWES
- Resp infexn
- Abortion
- Stillbirth
pre term labor
CS ng OVINE ENZOOTIC ABORTION OR ENZOOTIC
ABORTION OF EWES
Diagnosis ng OVINE ENZOOTIC ABORTION OR ENZOOTIC
ABORTION OF EWES
necropsy findinigs: puro sa placennta lang wala sa fetus t or f
vax?
Abortion sa late pregnancy
- Culture - definitive
- Complement fixation test - Western blot
- ELISA
- For surveillance
t
yes
Widespread in cattle in EU
- Caused by mycobacterium avium subspecies paratuberculosis
primarily spread via?
thiis dz ay same with ________ na nagrereplicate sa peyers AFTER inngestion
JOHNE’S DISEASE (PARATUBERCULOSIS)
feces/nursing
BSE
other routes transmission nng johnes dz/para
age risk factor
ZOONOTIC implication
Vectors (oriental cockroach, earthworms,
adlut dipterans, ovine trichostrongylid
larvae)
amitraz dips
under 30 days
Crohn’s dz: Enteritis in humans
4 stages of dz in cattle
stage 1 silent innfection shedding
2 infertility, mastitis
3 - loss bw, low milk, diarrhea WTHOUT blood (clinical dz)
4 - emaciation most obv (adv clinincal)
diagnostic test for johnsn dz in cattle
tx?
Fecal culture
- Most reliable
- 100% specificity and sensitivity
- Advantage: Detect silent infections
none. non vax prevention of nnew inf lang
Tick-transmissted
- Most pathogenic viral dz of small ruminants
what is variant in asia
what genuns annd fam?
san nagcirculate
vectors nnito? meron sa pinas?
nairobi sheep dz
Ganjam virus
genus Nairovirus of family Bunyavirdae
- Sri lanka - nagcirculate
Brown ear tick - rhipicephalus
appendiculatus: wala sa ph
Bont tick(amblyoma variegatum)
primary nakikita sa nnecropsy nng nairobi sheep dz
main organ affected?
may tx? may vax? meron sa pinnas report?
SplenomealyHemorrhages - primary
Abomasum - main organ affected
Zebra stripes
no tx; vax only; wla
Coxiella burnetti in cattle and waterbuffaloes, family rickettsiaceae
q fever
Bioterrorism like anthrax
mainn reservoirs?
ano transmission
q fever
cattle goat and sheep
(1) Sylvatic
- Wild animals’ cycle
- Birds to small mammals to rodents -
(2) domestic cycle
- Via tick bites
- Inhalation main in humans
- Transmission occurs During parturition
- Contaminated dust,
beddings, fomites, contaminated placenta, abortion materials,
