Zofran

Question 1

Zofran (??????)

CLASS:

Answer 1

Zofran (Ondansetron)

• Antiemetic

Question 2

Zofran (Ondansetron)

ACTION:

Answer 2

• Blocks serotonin receptors in vagus nerve terminals and in small intestine that trigger the vomiting reflex.
• ONSET = IV/IM, and ODT up to 30 min
• DURATION = IV/IM and ODT 2 hours

Question 3

Zofran (Ondansetron)

INDICATIONS:

Answer 3

Abdominal discomfort - GI/GU (nontraumatic) (S-120)
- For nausea or vomiting

Pain Management (S-141)
- For nausea or vomiting after morphine administration

Pediatric: GI/GU (Non-traumatic) (S-174)
- For nausea or vomiting

Question 4

Zofran (Ondansetron)

DOSAGE / ROUTE:

Answer 4

Adult only:
4 mg IV/IM/ODT
MR x1 in 10”

Peds:
1-3 Y/O: 2 mg ODT
3 years of age or greater 4 mg ODT
• If suspected head injury: BHPO

Question 5

Zofran (Ondansetron)

CONTRAINDICAATIONS:

Answer 5

• None

Question 6

Zofran (Ondansetron)

SIDE EFFECTS:

Answer 6

• GI symptoms, Especially diarrhea

* Headache

Question 7

Zofran (Ondansetron)

SPECIAL INFORMATION:
1.
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7.

Answer 7

(Concentration: Vial = 4mg/2ml for IV/IM or ODT = 4 mg for PO)

1. May cause mild hypotension and tachycardia
2. May cause profound hypotension when patient is taking APOkyn (Apomorphine Hydrochloride) a dopamine agonist used for Parkinsons disease.
3. Oral dissolving tablets (ODT) dissolve quickly but are somewhat fragile.
   
   • Do not push tablet through foil package.
   • Do not remove tablets from packaging until ready to administer to patient.
   • Place tablet on patients tongue and encourage patient to allow to dissolve; can be swallowed without water.
4. Anticipate the need for Zofran to treat nausea/vomiting side effect of morphine administration.
5. Dosing for Pediatric patients 1-3 years is 2mg ODT which is 1/2 of and ODT.
6. Pediatric patients with associated ? head injury require BHPO.
7. Zofran given by IO requires an MD variation.