Zhu Pharm

Question 1

Drug for MM in non-pregnant patients who’ve received 1+ previous tx

Answer 1

Lenalidomide

Question 2

Indicated for cutaneous manifestations of erythema nodosum leprosum

Answer 2

Thalidomide

Question 3

Drug used for immunotherapy

Answer 3

Rituximab

Question 4

Chimeric monoclonal antibody targeting CD20

Answer 4

Rituximab

Question 5

Drug for MM in non-pregnant patients who’ve previously tried 2+ tx

Answer 5

Pomalidomide

CONTRAINDICATED IN PREGNANCY

Question 6

Cardiotoxicity due to Doxorubicin can be reduced by co-administration of ___?

Answer 6

Dexrazoxane

Question 7

Blocks PDGF receptor-alpha

Answer 7

Imatinib

• a tyrosine kinase inhibitor targeting BCR-ABL

Question 8

Treatment of diffusue large B cell lymphoma

Answer 8

RCHOP

Question 9

Which drug do we give patients with relapsed APL?

Answer 9

Arsenic trioxide

• Targets PML of PML-RARA fusion protein

Question 10

What are the components of RCHOP chemotherapy?

What is RCHOP used for?

Answer 10

Rituximab

Cyclophosphamide, Doxorubicin, Vincristine, Prednisone

Indications: Follicular Lymphoma & DLBL

Question 11

What are the components of FCMR?

Answer 11

Fludarabine

Cyclophosphamide

Mitoxantrone

Rituximab

Question 12

AE of Bleomycin

Answer 12

Pulmonary toxicity

Question 13

Down-regulates cytokines

Increaseses NK cells, IL-2, INF-gamma

Anti-angiogenic

Answer 13

Thalidomide

• CONTRAINDICATED IN PREGNANCY!

Question 14

What are the components of the BR regimen

Answer 14

Bendamustine

Rituximab

Question 15

Induces leukemic cell apoptosis

Answer 15

Arsenic Trioxide

• Targets PML of PLM-RARA fusion product

Question 16

Inhibits DNA polymerase

Answer 16

Cytarabine

Question 17

Inhibits tumor & bone stromal cell interactions

MM cell growth arrest & apoptosis

Answer 17

Thalidomide

CONTRAINDICATED IN PREGNANCY

Question 18

Tx for MM resistant to 2+ prior tx

Answer 18

Carfilzomib

Question 19

Induces leukemic cell differentiation

Answer 19

Tretinoin

• targets RARA of PML-RARA fusion protein

Question 20

First line for ALL

Answer 20

Pegasparagase

Question 21

Inhibits AMP/GMP synthesis and de novo purine synthesis

Answer 21

6-Mercaptopurine

Question 22

Inhibits NF-kappa B activation

Answer 22

Bortezomib

Question 23

Incorporates into DNA only

Answer 23

Cytarabine

Question 24

Drug interaction with Allopurinol

What is Allopurinol usually given for?

Answer 24

6-mercaptopurine

Allopurinol used to prevent tumor lysis syndrome

Question 25

Drug given to pt with resistant CML

Intolerant to 2 previous tyrosine kinase inhibitors

Answer 25

Omacetaxine

• protein synthesis inhibitor

Question 26

Incorporates into both DNA and RNA

Answer 26

6-Mercaptopurine

Question 27

AE of Doxorubicin

Answer 27

Cardiotoxicity

Question 28

Drug for relapsed mantle cell lymphoma, or progressed after 2 prior tx

Answer 28

Lenolidomide

CONTRAINDICATED IN PREGNANCY

Question 29

What is the RCVP Regimen?

Answer 29

Rituximab

Cyclophosphamide

Vincristine

Prednisone

Question 30

Tx for newly diagnosed MM

Combo with Dexamethasone

Answer 30

Thalidomide

Question 31

3 indications for Cytarabine

Answer 31

AML

ALL

CML

Question 32

MOA of asparaginase & others

Answer 32

Catalyze deamination of asparagine

Asparagine –> Aspartate (neoplastic cells can’t use this for protein synthesis)

Question 33

Proteasome inhibitor

Indicated for MM (and) Mantle Cell lymphoma resistant to 1+ previous tx

Answer 33

Bortezomib

Question 34

Maintenance of ALL remission

Answer 34

6-Mercaptopurine

Question 35

Treatment of follicular lymphoma:

• Stages I & II –>
• Stages III & IV asymptomatic –>
• Stages III & IV symptomatic –>

Answer 35

• Stages I & II –> Radiation
• Stages III & IV ASx –> Watch-and-wait
• Stages III & IV Sx –> Chemotherapy (RCHOP), immunotherapy

Question 36

Drug for CML without drug interaction risks

Answer 36

Omacetaxine

Question 37

Irreversible proteasome inhibitor

Answer 37

Carfilzomib

Question 38

What is the regimen for Hodgkin Lymphoma?

What are the components?

Answer 38

ABVD

• Doxyrubicin
• Bleomycin
• Vinblastine
• Dacarbazine

Question 39

What drug is indicated for:

CLL

Indolent NHLs

Answer 39

Fludarabine