Benign Hyperplasia Flashcards
More common
Mediastinum, abdominal cavity
90% hyaline vascular type
10% plasma cell
Castleman Disease - Localized
Histology shows:
Interfollicular vascularity
Hyalinized vessels
Mantle cell lymphocytes show onion skinning
What disease is most likely?
Castleman Disease - Localized
Immunophenotype of Rosai-Dorman Disease
S100+
CD68+
CD1a -
Sinus histiocytosis with massive LAD
Rosai-Dorman Disease
Marked follicular hyperplasia
Sinusoidal dilation by monocytoid B-cells
Toxoplasmosis FH
Geographic follicles with germinal centers
Follicle lysis –> invaginating small lymphocytes in GCs
HIV-associated FH
Histolgy reveals active penetration of one cell by another which remains intact
Emperipolesis of Rosai-Dorman Disease
Small and large histiocytic aggregates within interfollicular areas and encroach upon GCs
Epithelioid granulomas of Toxoplasmosis FH
Interfollicular areas show multinucleated cells = Warthin Finkeldey cells
HIV-associated FH
Palisading histiocytes with central necrosis
Cat-Scratch Disease FH
Primary –> HHV-8
Almost all Plasma cell type
Castleman Disease - Multicentric (IL-6 Syndrome)
Which stain to detect Bartonella henselae?
Warthin-Starry stain