You Nasty! Flashcards
TORCH
Toxoplasmosis Other (syphilis) Rubella Cytomegalovirus (CMV) Herpes simplex virus (HSV)
What is a an important contributor to early and later childhood morbidity
infectious acquired in utero or during birth process
What are the only two prenatal screenings done in the U.S.
syphilis and rubella
How does Toxoplasmosis present in the baby?
Triad:
Chorioretinitis
Hydrocephalus
Intracranial calcifications
What is a late finding in toxoplasmosis due to failure to treat
chorioretinitis
What is seen in late finding for toxoplasmosis
intellectual disability, deafness, seizures and spasticity
What is the treatment for Toxoplasmosis
Pyrimethamine and Sulfadizine (folinic acid leucovorin)
Syphilis presentation in the baby?
asymptomatic at birth
How do babies get syphilis?
mother received no prenatal care, no PCN, or inadequate treatment before/during birth
Babies <2 show what syphilis manifestations?
syphilitic rhinitis (snuffles), maculopapular rash (palms), heptaosplenomegaly
Babies > 2 show what syphilis manifestations?
saddle nose, hutchinson teeth, saber shins, mulberry molars
Treatment for syphilis?
paraenteral penicillin
Rubella presentation in the mother?
mild, self limited illness
CRS presentation in the child?
sensorineural deafness, cardiac malformations, radiolucent bone disease, blueberry muffin, growth retardation
Where is CRS usually seen?
in infants who mothers emigrated from countries w/ no rubella vaccine
How is CRS treated?
Prevention is most important for management
Children with CRS are contagious until….
1yr
CMV presentation in baby?
asymptomatic, w/ 10% of symptoms
What is the most common congenital viral infection
Cytomegalovirus (CMV)
How does the mother get CMV?
close contact w/ young children, daycares
What is the most common defect in CMV babies?
Sensorineural hearing loss (1/3 detected @ birth)
CMV children are identified solely on the basis of what?
failed newborn hearing screen
What is the treatment for life threatening CMV?
Ganciclovir IV
What is the treatment for non-life threatening CMV?
Valganciclovir oral
What is the treatment for asymptomatic CMV?
NONE, antiviral is not needed!!
What are most cases of neonatal HSV infection?
Perinatally acquired HSV
How is perinatally HSV transmitted?
through infected maternal genital tract
How do perinatally infected HSV babies present?
normal @ birth
What ways do perinatally acquired HSV develop?
- Localized to skin, eyes, and mouth (SEM)
- Localized CNS disease
- Disseminated disease involving multiple organs
How does a congenital HSV baby present?
Triad:
Skin vesicles
Ulcerations
Scarring
Eye damage, severe CNS (microcephaly or hydranencephaly)
Treatment for Herpes?
Acyclovir
ZIKA presentation in mama?
asymptomatic
low grade fever, rash, arthralgia, conjuctivitis
ZIKA presentation in baby?
microcephaly, arthrogryposis, facial disproportion
When is the greatest risk for ZIKA?
1st trimester
Treatment for ZIKA?
NONE, supportive
What are the two most important approaches to preggo patient?
Timely diagnosis, high index of suspicion
3 viral vulvar lesions?
Condyloma acuminata
Molluscum Contagiosum
HSV
Which HPV strains cause genital warts
6 and 11
Treatment for condyloma acuminata?
patient- Imiquimod cream, Podofilox gel, Sinecatchins
provider- TCA, cryotherapy, surgical removal
Mollusucum contagiosum is caused by what virus?
pox virus
Mollusucum contagiosum treatment?
resolves in 6-12 mo or up to 4yrs
physical removal: cryotherapy, curettage, laser
oral: cimetidine
topical: podophyllotoxin cream (NOT FOR PREGGO)
Treatment for initial, episodic, and suppressive therapy for genital HSV?
Acyclovir or Valacyclovir
Treatment for intital epsoide of HSV?
Acyclovir oral
Valacyclovir
Treatment for episodic therapy of HSV?
Acyclovir oral
Valacyclovir oral
Treatment for suppressive therapy of HSV?
Acyclovir oral
Valacyclovir oral
3 bacterial vulvar lesions?
Folliculitis
Chancre Syphilis
Chancroid
What two bugs cause folliculitis?
Staph aureus, pseudomonas aeruginosa (hot tub)
Treatment for folliculitis?
resolves 2 wks
avoid shaving, warm compress
topical abx: mupirocin
oral abx: dicloxacillin
Syphilis treatment?
Bezathine penicillin G IM single dose
Followup for syphilis period?
6 and 12 months
Diagnosis of syphilis?
Nontreponemal test (VDRL or RPR) and Treponemal test (FTA-ABS)
What causes Chancroid?
Haemophilus ducreyi
What two test if negative may lead to a chancroid diagnosis?
syphilis and HSV
Treatment for chancroid?
Azithromycin
Ceftriazone
Follow-up for chancroid?
re-examine 3-7 days
Candidiasis is caused by what?
Candida albicans (90%)
Whom are candidiasis infections more likely seen?
preggo, diabetics, obese, immunosuppressed, OCP, abx, steroids
Symptoms of a candidiasis infection
itching, burning, irritation
How does the discharge look in a candidiasis infection?
white curdy, cottage cheese, thick
What is seen on wet mount for candidiasis?
hyphae and buds
Treatment for candidiasis?
Oral fluconazole 150mg x1 or Imadizoles
MC bacterial infection organism?
Gardnerella vaginalis
What is seen on wet mount for bacterial infection?
clue cells
Treatment for bacterial infection?
Metronidazole gel or Clindamycin cream
How does the discharge look in a bacterial infection?
yellow, gray-white, thin adherent
Symptoms of a bacterial infection
fishy odor, gets worse after sex, ph>4.5, + whiff test
3 types of cervicitis?
Chlamydia
Gonorrhea Trichomoniasis
Most reported cervicitis?
Chlamydia
Treatment for chlamydia?
Azithromycin or doxycycline
Follow up for chlamydia?
All women retest 3mo
2nd most common cervicitis?
Gonorrhea
Symptoms of gonorrhea?
male- urethritis
female- overlooked
Appearance of discharge in gonorrhea?
greenish or yellow
Treatment for Gonorrhea?
Ceftraixone IM AND Azithromycin
What organism is associated w/ PID, endometritis, infertility, ectopic/preterm
Trichomoniasis vaginalis
Symptoms of trichomoniasis?
itching, burning, copious discharge, dysuria, dyspareunia, frothy discharge
Treatment for trichomoniasis?
Metronidazole oral OR tinidazole oral
Diagnosis of trichomoniasis?
petechiae “strawberry patches”
Two organisms that cause PID?
C. trachomatis and N. gonorrhea
Symptoms of PID?
Muscular guarding, cervical motion tenderness, adnexal tenderness, pelvic exam, fever, chills
PID parenteral treatment?
Cefotetan IV or Cefoxitin IV PLUS Doxy IV
PID outpatient treatment?
Ceftriaxone IM x1 PLUS Doxycycline +/- Metronidazole for 14dy