Year 4 Flashcards
Most common side effect of macrolides?
Jaundice
What is Polymyalgia Rheumatica?
Pain and inflammation in many joints and tissues around the joints Particularly effects: ○ Shoulders ○ Neck ○ Hip
What is Bigeminy
alternating ventricular ectopic beat (wide QRS) and sinus beat (with narrow QRS).
What is HPOA?
HPOA - hypertrophic pulmonary osteoarthropathy
• Clubbing and periostitis
• Test for be palpating the wrists for tenderness
Mechanism thought to be the same as for clubbing - megakaryoctes and large platelets manage to find their way into the systemic circulation and release lots of growth factors
What is tazocin?
Piperacillin and tazobactam combo antibiotic
What is tazocin’s range of effect?
Includes
• Gram positive
• Gram negative
• Pseudomonas aeriginosa
What is Indapamide?
A thiazide like diuretic
Generally used in the treatment of HT
What is the common low molecular weight heparin?
Enoxaparin/ Clexane
What is apixaban?
A Factor Xa inhibitor
Used for treatment of thromboembolism and for prophylaxis also
Nimodipine
Ca channel blocker
Classes of antiarrhythmics?
- Na channel blockers
- Beta Blockers
- K channel Blockers
- Ca Channel blockers
- Other
What are some Type 1 Antiarrythmics?
Lignocaine
What is atropine
An Ach receptor antagonist, can be given for bradycardia.
What are some Type 2 Antiarrythmics?
Atenolol, metoprolol, carvedilol, propranolol, bisoprolol
What are some Type 3 Antiarrythmics?
Amiodorone
Sotalol
What are some Type 5 Antiarrythmics?
Adenosine
Digoxin
Name a K binder
Resonium
Trimethoprim
An Abx used to treat UTIs
Aspirin’s antithrombosis MOA
Decreased production of Thromboxane A2 by COX-1. Thromboxane A2 normally mediates the expression of GP IIb/ IIIa on platelet membranes. This is usually responsible for fibrinogen binding to and binding the platelets together.
Narrow spectrum Penecillin with staph action?
flucloxacillin
What class of Abx is gentamycin
aminoglycaside
What are some Type 4 Antiarrythmics?
Verapamil
Treatment for migraines?
Acute: Mg
If severe: Triptan (sumitriptan)
Supportive: NSAIDs/ Aspirin, anti-emetics, hydration
Donepezil
- Reversible cholinesterase inhibitor
* Used to treat dementia
Acute abdomen causes
- Appendicitis
- Kidney stone - ureteric colic
- Biliary colic / cholecystitis
- Ectopic pregnancy
- Salpingitis
- Bowel obstruction
- Bowel ischaemia
- AAA
- Diverticulitis
- Pancreatitis
borders of the anterior triangle of the neck
sternomastoid
line from chin to manubrium
inferior aspect of the jaw
what anti-arrhythmic can be used to cardiovert?
amiodorone, sotolol, lignocaine (only in emergencies for ventricular arrhythmias)
Diff between Bell’s palsy and stroke on examination
Bell’s palsy also causes weakness of forehead muscles as is a LMNL. Forehead gets dual innervation from both cerebral cortexes so the deficit isnt pronounced in stroke.
borders of the anterior triangle of the neck
sternomastoid
line from chin to manubrium
inferior aspect of the jaw
Most common cause of facial nerve palsy
Bell’s palsy
Diff between Bell’s palsy and stroke on examination
Bell’s palsy also causes weakness of forehead muscles as is a LMNL. Forehead gets dual innervation from both cerebral cortexes so the deficit isnt pronounced in stroke.
sialolithiasis most common gland affected
submandibular (90%)
Sentinal node is….
any LN which receives DIRECT drainage from a particular area (not just the FIRST node)
histology of papillary thyroid carcinoma
psammoma bodies (concentric lamellated calcified structures)
cells found in histology suggestive of lymphoma
Reed-Sternberg cells
histology of papillary thyroid carcinoma
psammoma bodies
most common type of thyroid ca
papillary carcinoma (70%)
surveillance marker for disease recurrence after total thyroidectomy for papillary carcinoma
thyroglobulin
thyroid papillary carcinoma prognosis after thyroidectomy
90% 10year survival
Which NOAC is not a factor Xa inhibitor?
Dabigatran (direct thrombin inhibitor)
What is Bivalirudin?
A direct thrombin inhibitor,
Doesn’t cause HITTS, recommended in ACS
What nerve are you likely to damage with a mid humoral fracture?
Radial
What muscles does the median nerve supply?
- All the flexors of the forearm except flexor Capri ulnaris
- LOAF muscles
- Lumbricals (1st and second)
- Opponens pollicis
- Abductor pollicis brevis
- Flexor pollicis brevis
Side effects of parotidectomy…?
Frey’s syndrome (gestatory diaphoresis)
Damage to the facial nerve
Salivary fistula
What is Uhthoff’s phenomenon…?
Worsening of neurological symptoms with heat/exercise. Seen with demyelinating disorders e.g. MS
Investigation to confirm TB eradication…?
Sputum culture with Ziel Nielson stain for acid fast bacilli
What is a Colles fracture…?
FOOSH with extra-articular fracture of distal radius and dorsal displacement.
What is a Smith fracture…?
FOOSH (flexed), with extra-articular fracture of distal radius and palmar displacement.
Type 1 vs Type 2 statistical error?
Type 1: false positive (incorrectly rejecting the null hypothesis)
Type 2: false negative
What is the inheritance and pathology of Haemophilia A?
X linked recessive, decreased factors VIIIc.
Some carriers can have decreased factor VIII which can lead to heavier bleeding
DDx for Acute abdomen with pain in RLQ
Appendicitis Mesenteric adenitis (young) Salpingitis Ectopic pregnancy Ureteric colic Pyelonephritis Diverticulitis Crohn's disease
Orientations/Locations of the appendix
Retrocaecal (75%)
Pelvic (20%)
Ileal (5%)
Muscles inserting into Pes Anserinus…?
Gracilis, Sartorius and Semitendinosus
Causes of hyperuricaemia…?
Overproduction: ETOH, psoriasis, myeloproliferative disorders.
Underexcretion: Renal failure, diuretics, dehydration, starvation, low dose aspirin.
What is a Colles fracture…?
FOOSH with extra-articular fracture of distal radius and dorsal angulation.
What is a Smith fracture…?
FOOSH (flexed), with extra-articular fracture of distal radius and palmt5frar angulation.
What is tennis elbow…?
Lateral epicondylitis, caused by tear of extensor carpi radialis brevis.
What is golfer’s elbow…?
Medial epicondylitis, caused by tear to flexor carpi redialis
Muscles of the rotator cuff…?
Supraspinatus, infraspinatus, teres minor, subscapularis
Criteria for rheumatic fever
Jones criteria Evidence of streptococcal infection Major - pancardiits - migratory polyarthritis - erythema marginatum - sydenham chorea - subcut nodules
Minor
- fever
- arthalgia
- PHx rheumatic heart disease or fever
- Acute phase reactions (ESR, CRP, leukocytosis)
- prolonged PR