Y2 Connective Tissue Disease Immunology Flashcards

1
Q

Which type of hypersensitivity reaction is Rheumatoid Arthritis?

A

Type IV

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2
Q

Which type of hypersensitivity reaction is SLE?

A

Type III

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3
Q

Which HLA allele is susceptible in SLE?

A

HLA-DR3

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4
Q

Which HLA allele is susceptible in ankylosing spondylitis?

A

HLA-B27

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5
Q

Which disease is anti-centromere antibody associated with?

A

CREST / limited scleroderma

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6
Q

Which disease is anti-la associated with?

A

Sjogren’s syndrome

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7
Q

Which disease is anti-Jo-1 associated with?

A

Polymyositis

Dermatomyositis

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8
Q

Which disease is anti-Ro associated with?

A

SLE

Sjogren’s syndrom

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9
Q

Which disease is anti-ribonucleoprotein (anti-RNP) associated with?

A

SLE

Mixed Connective Tissue Disease

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10
Q

Which disease is anti-Smith (anti-Sm) associated with?

A

SLE (very specific)

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11
Q

What disease is Anti-dsDNA associated with?

A

SLE (very specific)

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12
Q

What disease is Anti-scl-70 associated with?

A

Diffuse Sclerosis

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13
Q

What disease is Anti-Cardiolipin associated with?

A

Anti-phospholipid syndrome

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14
Q

What disease is Anti-CCP associated with?

A

Rheumatoid Arthritis

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15
Q

What antibodies are found in SLE?

A

Anti-dsDNA (specifically) also Anti-Sm, anti-ANA and anti-ENA

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16
Q

What antibodies are found in Sjogren’s syndrome?

A

Anti-Ro and Anti-La

17
Q

What antibodies are found in Limited sclerosis?

A

Anti-centromere

18
Q

What antibodies are found in Diffuse Sclerosis

A

Anti-scl-70

19
Q

What antibodies are found in Mixed CTD

A

Anti-RNP

20
Q

What antibodies are found in Anti-phospholipid syndrome?

A

Anti-Cardiolipin

21
Q

What antibodies are found in Rheumatoid Arthritis

A

Not all will have Ab.

If they do: Anti-CCP (specific) also Anti-RF (not specific)