Y2 Connective Tissue Disease Immunology Flashcards
Which type of hypersensitivity reaction is Rheumatoid Arthritis?
Type IV
Which type of hypersensitivity reaction is SLE?
Type III
Which HLA allele is susceptible in SLE?
HLA-DR3
Which HLA allele is susceptible in ankylosing spondylitis?
HLA-B27
Which disease is anti-centromere antibody associated with?
CREST / limited scleroderma
Which disease is anti-la associated with?
Sjogren’s syndrome
Which disease is anti-Jo-1 associated with?
Polymyositis
Dermatomyositis
Which disease is anti-Ro associated with?
SLE
Sjogren’s syndrom
Which disease is anti-ribonucleoprotein (anti-RNP) associated with?
SLE
Mixed Connective Tissue Disease
Which disease is anti-Smith (anti-Sm) associated with?
SLE (very specific)
What disease is Anti-dsDNA associated with?
SLE (very specific)
What disease is Anti-scl-70 associated with?
Diffuse Sclerosis
What disease is Anti-Cardiolipin associated with?
Anti-phospholipid syndrome
What disease is Anti-CCP associated with?
Rheumatoid Arthritis
What antibodies are found in SLE?
Anti-dsDNA (specifically) also Anti-Sm, anti-ANA and anti-ENA
What antibodies are found in Sjogren’s syndrome?
Anti-Ro and Anti-La
What antibodies are found in Limited sclerosis?
Anti-centromere
What antibodies are found in Diffuse Sclerosis
Anti-scl-70
What antibodies are found in Mixed CTD
Anti-RNP
What antibodies are found in Anti-phospholipid syndrome?
Anti-Cardiolipin
What antibodies are found in Rheumatoid Arthritis
Not all will have Ab.
If they do: Anti-CCP (specific) also Anti-RF (not specific)
