Y1 Gastroenteritis Organisms and Treatment Flashcards
Treatment of:
Mild spontaneous bacterial peritonitis
Co-trimoxazole
Treatment of:
Severe spontaneous bacterial peritonitis
Tazobactam & Piperacillin
Treatment of:
Peritonitis: biliary tract / intra-abdominal
IV Amoxicillin + Metronidazole + Gentamicin
What is the Sepsis 6 Bundle?
BUFALO
Bloods (take) Urine hourly output (take) Fluids (give) Antibiotics (give) Lactate (take) Oxygen (give)
Treatment of:
C. Diff
Metronidazole or Vancomycin
Treatment of:
Campylobacter
Clarithromycin
Treatment of:
Salmonella
Ciprofloxacin
Treatment of:
Shigella
Ciprofloxacin
Causes bloody diarrhoea (acute colitis)
Campylobacter, Shigella, E.coli 0157, amoebiasis
Have pre-formed toxins
Staph aureus, Bacillus cereus, Cl. Perfringes, E.coli 0157
Detection via:
Microscopy
Parasites
Detection via:
ODG
Giardia (green stools)
Detection via:
Culture
Salmonella, Shigella, Campylobacter, Cholerae
Detection via:
Toxin
C. Diff & E.coli
Detection via:
PCR
Norovirus & Rotavirus
Has a short incubation time of 1-6hrs
Staph aureus / Bacillus Cereus
Has a medium incubation time of 12-48hrs
Salmonella / Clostridium Perfringes
Has a long incubation time of 2-14 days
E.coli 0157
Campylobacter (cause you’d go camping for a long time to make it worthwhile)
The 4 C’s of C. Diff
Cephalosporins Clindamycin Ciprofloxacin (quinolones) Co-amoxiclav The 5th C = Clarithromycin (i know, its stupid when it's called the 4 C's)
Food poisoning from:
Re-heated rice
Bacillus Cereus (sounds like cer-rice)
Food poisoning from:
Whipped Cream
Staph aureus
What is gastroenteritis and what is the consequence regarding absorption?
Inflammation of stomach and small intestine
Limits absorption of nutrients and water
Acute enteritis often presents with fever, diarrhoea, vomiting and abdo pain. Is the diarrhoea usually bloody?
No
Acute colitis often presents with fever, diarrhoea and abdo pain. Is the diarrhoea usually bloody?
Yes
Which out of bacteria, viruses and parasites is the most common cause of gastroenteritis?
Viruses
Which antibiotic is commonly used for non-severe C. diff?
Oral Metronidazole
Which antibiotic is used for severe C. diff?
Oral vancomycin
never IV
What is meant by antimicrobial stewardship?
Prescribing optimum dosage and duration of antimicrobial treatment that results in best clinical outcome, prevention of infection and minimal resistance
Who is most at risk of complications from E. coli 0157 infection?
Children and Elderly
Which antibiotic is used for amoeba and giardia infections?
Metronidazole
How is rotavirus spread?
Faeco-oral
How is norovirus spread?
Faeco-oral and droplets
Which type of culture - urine, stool or blood - is key to diagnosing typhoid?
Blood
What is first line treatment for gastroenteritis?
Oral rehydration or IV fluids
Describe the nature of vomiting that comes with norovirus
Explosive and sudden
Lead to environmental contamination
(yum…)
Which stool investigation is appropriate for Giardia, Amoebas and parasitic infections?
Stool microscopy
Which stool investigation is appropriate for Clostridium Difficile and E. coli 0157?
Stool Toxin
What is the name of the toxin produced by E. coli 0157?
Verotoxin (VTEC)
Name the 4 main stool investigations for infectious organisms, from most used to least
Stool culture
Stool microscopy
Stool toxin
Stool PCR
Which antibiotic is used for first recurrence of C. diff infection?
Fidaxomycin
What is the incubation period for Campylobacter and E. coli 0157?
Long
2-14 days
Which organism is the most common cause of traveller’s diarrhoea?
E.coli 0157
What is meant by toxin-mediated food poisoning?
Toxin has been preformed by the bacteria on the host before ingestion of food, leading to acute symptoms once the food has been eaten
Which organism is the commonest cause of food poisoning?
Campylobacter
Define SIRS (systemic inflammatory response syndrome)
More than 2 of:
Temperature <36 or >38
RR over 20
WCC less than 4k or over 12k
Which foods does Campylobacter mainly colonise?
Poultry
Raw milk
Poor food preparaiton
What are the main organisms that cause bloody diarrhoea?
Campylobacter
Shigella
E. coli 0157
Amoebas
Which foods does E. coli 0157 colonise?
Beef
Raw milk, water
Wide variety really
Which foods does Salmonella mainly colonise?
Poultry
Raw egg
Meat, animal guts
What is the commonest cause of viral diarrhoea in kids under 3 years old?
Rotavirus
Which virus is known as the winter vomiting bug?
Norovirus
What is the incubation period for bacillus cereus and staph aureus?
Short
1-6hrs
Typhoid is an enteric fever like illness caused by which organism?
Salmonella
Which organisms are more likely to cause outbreaks of food poisoning?
Salmonella and E.coli 0157
Define sepsis
SIRS + suspected/confirmed underlying infectious process
Which 3 markers assess the severity of C. difficile infection?
Suspicion of pseudomembranous colitis/toxic megacolon/ileus
WCC greater than 15
High creatinine
What is the incubation period for Salmonella and Cl. perfringens?
Medium
12-48hrs
Which syndrome can result due to verotoxin?
Haemolytic uraemic syndrome