Xenobiotics

Question 1

Phase I is ……. By……..

Answer 1

Hydroxylation

CYP 450 “mono oxygenase”

Question 2

Number of CYP 450 genes

Answer 2

At least 57

Question 3

CYP 450 is …….dependant

Answer 3

NADPH+H

Question 4

If a patient has low enzymatic activity of CYP 450 this leads to……

Answer 4

Prolonged drug action and accumulation of the drug

Question 5

Variation of drug response from one to another due to…..

Answer 5

Enzyme polymorphism

Question 6

…….are inducers of CYP 450

Answer 6

Phenobarbital

Question 7

Mitochondrial CYP450 imp in

Answer 7

Steroid hormone synthesis
Bile acid synthesis
Vit D3 hydroxylation and activation

Question 8

Phase II is ……

Answer 8

Conjugation

Question 9

Glucuronyl donor …..

Answer 9

UDP-Glucuronic

Question 10

Glucuronidation occurs in

Answer 10

Bilirubin
Steroid hormones
Aspirin

Question 11

…….is active S donor

Answer 11

PAPS 3 phophoadenosyl 5 phosphosulfate

Question 12

Sulfation occurs in…..

Answer 12

Steroids and alcohol

Question 13

Glycine+……… Gives…….

Answer 13

Benzoic acid

Hippuric acid

Question 14

………rate of production is an index of liver function

Answer 14

Hippuric acid

Question 15

Acetyl CoA binds…….

Answer 15

Nitrogen of aromatic amine

Question 16

……..for nicotinamide

Answer 16

Methylation

Question 17

……..for histamine and isoniazid

Answer 17

Acetylation