Jaundice Flashcards
Why does jaundice appear in skin and sclera?
Because they contain elastin which has high affinity for bilirubin
Normal level of bilirubin in plasma……
0.3-1mg/dl
…….is called hyperbilirubinemia
1-2mg/dl
Bilirubin above 2mg/dl is
Jaundice
Jaundice can be classified according to…….
Type of bilirubin
Anatomical site of defect
Pre-hepatic jaundice is due to…..
Increased hemolysis
Normal stool and urine color in ……. Jaundice
Pre-hepatic
Type of bilirubin elevated in hepatic jaundice
Direct and indirect
Urobilinogen is absent in …… jaundice
Post-hepatic
Kernicterus occurs when bilirubin is above……
20-25mg%
Only…….bilirubin can cross BBB in neonates
Unconjugated
Ttt of neonatal jaundice
Phototherapy
Phenobarbital
……….is not affected by phenobarbital
Crigler-Najjar syndrome type 1
Cause of Gilbert syndrome
Deficient glucuronyl transferase enzyme
……..is characterized by complete absence of glucuronyl transferase
Type 1 of Crigler-Najjar syndrome