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Respiratory Pharma > Xantines > Flashcards

Xantines Flashcards

1
Q

Example

A

Theophylline

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2
Q

MoA

A 
Phosphodiesterase
Inhibitor
Reduces breakdown of cAMP/cGMP
Block adenosine receptors
Activates histone deacetylase to reverse resistance to corticosteroid
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3
Q

Indications

A

Steps 3/4 Asthma

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4
Q

ADR

A

Dysrhythmia

Seizures

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5
Q

Prescribing Advice

A

Metabolised by CYP450 enzyme in Liver
Narrow Therapeutic Window
X Heart conditions, Acute Porphyria
Jaundice in neonates

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Respiratory Pharma (6 decks)

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