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Toxicology > Written: PP > Flashcards

Written: PP Flashcards

1
Q

Which of the following symptoms is characteristic in lead (Pb) Poisoning?

a. Paralysis of the radial nerve.
b. “Rice water” stool
c. Acute renal failure
d. Plantar hyperkeratosis
e. Respiratory insufficiency

A

a. Paralysis of the radial nerve.

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2
Q

Which of the following is NOT typical for mercury (Hg) poisoning?

a. acute renal failure
b. microcytic anemia
c. bloody stool
d. neuropathy
e. acrodynia (painful extremities)

A

b. microcytic anemia

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3
Q

Chronic arsenic poisoning can be detected from: a. Hair b. Bone Marrow c. Urine d. Liver biopsy e. CT examination

A

a. Hair

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4
Q

Which of the following is NOT characteristic for arsenic (As) poisoning?

a.

b.

c.

d.

e. Methemoglobinemia

A

e. Methemoglobinemia

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5
Q

Which of the following can be applied in alkaliphosphate poisoning?

a. Atropine

b.

c.

d.

e.

A

a. Atropine

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6
Q

Which of the following mechanisms describe the action of DNOC?

a. binding to the SH-groups of proteins
b. Detaching oxidative phosphorylation
c. protein preciptation
d. methemoglobin formation
e. inhibition of cytochrome oxidase

A

b. Detaching oxidative phosphorylation

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7
Q

Which of the following chelators can be used in iron poisoning? a. Deferoxamine b. Dimercaprol c. Succimer d. Co-EDTA e. D-pencillamine

A

a. Deferoxamine

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8
Q

Which of the following symptoms is characteristics to CO poisoning?

a. paralysis of the radial nerve
b. extreme pupil constriction
c. Severe headache
d. bloody stool
e. methemoglobin

A

c. Severe headache

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9
Q

In CO poisoning you have to do EXCEPT:

a. Oxygen inhalation
b. Hemodialysis
c. Diazempam injection
d. Corticosteriod or mannitol to prevent cerebral edema
e. Treating acidosis

A

b. Hemodialysis

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10
Q

Which of the following is forbidden in acid-base poisoing?

a. to give milk or water
b. restoring plasma pH
c. to give morphine
d. to provoke emesis
e. infusion

A

d. To provoke emesis

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11
Q

Which of the following statements describe similarities between oxalic acid and base poisoning?

a. Both cause coagulative necrosis
b. Both cause colliquative necrosis
c. Both may cause tetany
d. Both are nephrotoxic
e. Both are hepatotoxic

A

c.Both may cause tetany

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12
Q

Which of the following permanent damage is typical after surviving methanol intoxication?

a. uremia
b. Blindness
c. esophagus stricture
d. aphasia
e. bone marrow suppression

A

b. Blindness

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13
Q

Which of the following should be done in ethylene glycol poisoning?

a. To give chelators
b. Oxygen inhalation
c. To give ethanol
d. To make methemoglobin with nitrites
e. To give liver protective drug (e.g. silymarin, silibinin)

A

c. To give ethanol

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14
Q

Which of the following is the most appropriate treatment of cyanide poisoning?

a. dimercaprol or other chelators
b. only sympathomatic treatment
c. to create methemoglobin with NaNO2 then to give Na2S202.
d. morphine -atropine combustion
e. to give vitamin b12

A

c. to create methemoglobin with NaNO2 then to give Na2S202.

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15
Q

Which of the following statements is true about Amanita falloides poisoning?

a. The poisoning has two phases.

b.

c.

d.

e.

A

a. The poisoning has two phases.

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16
Q

Mechanism of nerve gases:

a.

b.

c.

d. irreversible acetylcholinesterase inhibitors

e.

A

d. irreversible acetylcholinesterase inhibitors

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17
Q

Which of the following symptoms is NOT characteristic to organophosphate poisoning?

a. muscle rigidity
b. vomiting
c. bronchoconstriction
d. salivation
e. hypotension

A

a. muscle rigidity

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18
Q

What is the most severe complication of chronic benzene poisoning?

a. severe bone marrow suppression

b.

c.

d.

e.

A

a. severe bone marrow suppression

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19
Q

Which of the following cholinesterase inhibitors may antagonize the CNS symptoms of atropine poisoning?

a. neostigmine
b. distigmine
c. pyridostigmine
d. physostigmine
e. edrophonium

A

d. physostigmine

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20
Q

Which of the following symptoms is typical to botulism. EXCEPT:

a. maintained consciousness
b. muscle paralysis
c. double vision
d. intestinal paralysis
e. epileptiform seizures

A

e. epileptiform seizures

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21
Q

Botulinsm-what is wrong:

A

Neostigmine is not given

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22
Q

What is not a symptom from methanol intoxication:

A

Irritation of gastric mucosa

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23
Q

What is not correct about acid and base intoxication?

A

U can give sodium bicarbonate for base

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24
Q

What is a symptom for gasoline intoxication?

A

Bradycardia

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25
Q

What is correct about mushroom muscarina?

A

Contains toxic alkaloids

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26
Q

What is not a symptom for chronic lead intoxication?

A

Erethism

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27
Q

6)What is not used for cyanide intoxication?

A

Thionin

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28
Q

5)In which % symptoms of CO appear?

A

( there was 10-30(actually 25%), 30-50 and so on, i…answer is 30-50%)

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29
Q

3)What is true: elementary mercury:

A

via inhalation

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30
Q

Which of the following statements is (not?) characteristic to CO poisoning?

a. formation of COHb is irreversible
b. NaCO3 can be given iv if necessary
c. mannitol can be given if necessary
d. symptoms of poisoning are headache, dizziness, acidosis
e. 60%COHb level in lethal

A

a. formation of COHb is irreversible.

31
Q

Which of the following poisonings may induce hepatotoxicity?

a. methanol
b. CCL4
c. methyl mercury
d. mushrooms containing toxic alkaloids
e. acid

A

b. CCL4 (Carbon tetrachloride)

32
Q

Which of the following statements is not true for cyanide poisoning?

a. it is characterized by asphyxia
b. it is characterized by hyperventilation
c. its antidote is methylene blue
d. cyanide binds to the trivalent iron
e. in the body cyanide is transforemed to rodanate (SCN-)

A

e.in the body cyanide is transforemed to rodanate (SCN-) ?? *(c. its antidote is methylene blue….antidote is hydroxycobalamin and Na-nitrite + Na thiosulfate )

33
Q

Which of the following states is true for intoxication with amanita phalloides?

a. it is characterized with severe liver- and kidney damage.
b. its therapy is atropine.
c. symptoms may appear within 2-3 hours.
d. its lethality is not very high.
e. its first symptom is the hypoxia.

A

a. it is characterized with severe liver- and kidney damage.

34
Q

Which of the following states is not true?

a.

b.

c. 20% methemoglobin concentration in the blood is lethal.

d.

e.

A

c. 20% methemoglobin concentration in the blood is lethal.

35
Q

Which of the following is antidote in methanol intoxication?

a. deferoxamine
b. NaCa-EDTA
c. activated charcoal
d. ethanol
e. methylene blue

A

d. ethanol

36
Q

Which of the followings is dithiol chelator?

a. pralidoxime
b. NaCa-EDTA
c. succimer
d. naloxone
e. methylene blue

A

c. succimer

37
Q

Which of the followings is a characteristic symptom of chronic arsenic poisoning?

a. Diarrhea
b. Blindness
c. Peripheral neuropathy
d. Gingivostomatitis
e. Hyperventilation.

A

c. Peripheral neuropathy (Polyneuritis **)

38
Q

Which of the following symptoms is typical for acid poisoning?

a. Coagulational necrosis
b. liquefactive (colliquational) necrosis
c. encephalopathy
d. tetany
e. hepatitis

A

a. Coagulational necrosis

39
Q

Which of the following poisons may result in blindness?

a. mercury
b. arsenic
c. ethylene glycol
d. methanol
e. nitrobenzol

A

d. methanol

40
Q

Which of the following poisons may result in methemoglobinemia? a. mercury b. cyanide c. lead d. amyl nitrite e. DNP

A

d. amyl nitrite

41
Q

Which of the followings can be applied in organophosphate poisoning? a. physostigmine b. atropine c. ethanol d. fomepizol e. naloxone

A

b. atropine

42
Q

Which of the following mechanisms describe the action of cyanide poisoning? a. inhibition of cellular respiration b. induction of anemia c. formation of methemoglobinemia d. coagulational necrosis e. binding to the hemoglobin

A

a. inhibition of cellular respiration

43
Q

Which overdose would you recognise from the following symptoms: pinpoint pupils, respiratory depression, coma.

A

opioid overdose

44
Q

CCl4 might cause: a. hepatic damage b. kidney damage c. blindness d. fever

A

a. hepatic damage (potent hepatotoxin- used in research)

45
Q

Minimal brain dysfunction is typical in the following intoxication: a. arsenic b. mercury c. lead d. cyanide

A

a. arsenic

46
Q

which toxin is responsible for the hepatotoxicity in mushroom poisoning? a. muscarine b. muscimol c. amanitin d. obidoxime

A

c. amanitin

47
Q

which of the following substances cause symptoms similar to acid poisoning? a. glycerine b. formaldehyde c. benzol d. parathion

A

b. formaldehyde

48
Q

Which of the following substances increases the activity of rhodanese? a. Na nitrite b. EDTA c. Methylene blue d. Na thiosulfate

A

d. Na thiosulfate

49
Q

which of the following substances may cause methemoglobinemia? a. mercury b. cyanide c. lead d. amyl nitrite

A

d. amyl nitrite

50
Q

what is the symptom of chronic arsenic intoxication? a. diarrhea b. blindness c. peripheral vascular disease d. hematemesis

A

c. peripheral vascular disease (polyneuritis)

51
Q

What is the symptom of acute mercury intoxication? a. tremor b. ataxia c. oligouric kidney failure d. anorexia

A

c. oligouric kidney failure

52
Q

What is the antidote of methanol? a. ethanol b. EDTA c. activated charcoal d. deferoxamine

A

a. ethanol

53
Q

what is the antidote of benzodiazepines? a. Naloxone b. Physostigmine c. Acetylcysteine d. Flumazenil

A

d. Flumazenil

54
Q

Which one is a chelator from the following substances? a. pralidoxime b. succimer c. naloxone d. succinylcholine

A

b. succimer

55
Q

1 and 2 symptoms of chronic/acute arsenic/ mercury poisoning?

A

**. was options like blindess, puking blood, acute kidney failure, diarrhea, peripheral vascular disease. I can’t remember more options

56
Q

Antidotes of: - benzodiazepines -organophosphates -atropine

A
  • flumazenil - o2 + atropine and pralidoxime. decontaminate - airways, lavage and activated charcoal
57
Q

what does acid poisoning poisoning cause? both cogulative necrosis and tetany were in the options

A

coagulative necrosis

58
Q

what causes blindness?

A

methanol not an option, formic acid and glycol ethylene were. (formic acid and formaldehyde are the by-products of methanol)

59
Q

what is the toxin causing hepatotoxicity in the mushrooms. Amanitin or something like that smile emoticon

A

toxic polypeptide (amatoxin) inhibits RNA polymerase 2

60
Q

Doesn’t cause MetHb:

A

gasoline

61
Q

Snake poison:

A

includes all of the above toxins

62
Q

Forbidden for acid base:

A

to neutralize with weak acid/base. instead give NaHCO3 by i.v.

63
Q

which of the following drugs does not cause methemoglobinemia? a. alanin b. potassium perchlorate c. gasolin d. methylene blue e. sodium nitrite

A

c. gasolin

64
Q

which of the following drugs cause similar symptoms to acid poisoning a. phenol b.ethylene glycol c. benzene d. dinitro-phenol e. carbon tetrachloride.

A

a. phenol

65
Q

characteristic to lead (Pb) poisoning?

A

microcytic anemia with basophil spots

66
Q

toxin not present in snake poison? a. neurotoxin b. anticoagulant c. cardiotoxin d. inhibitor e. all of them

A

e. all of them

67
Q

the symptoms of atropine overdose can be: a. diarrhea b. increasesd secretion of saliva c. fever d. bradycardia

A

c. fever hot as a hare, blind as a bat, dry as a bone, red as a beet, mad as a hatter.

68
Q

what is the antidote for irreversible acetylcholinesterase blockers? a. physostigmine b. pralidoxime c.parathion d. carbachol

A

b. pralidoxime

69
Q

which of the following chelators can NOT be given orally? a. succimer b EDTA c. dimercaprol d. deferoxamine

A

c. dimercaprol

70
Q

Whic of the following is not used for treatment of CO poisoning? a. O2 inhalation b. diazepam injection c. administration of glucocorticoids d. hemodialysis e. NaHCO3 infusion

A

d. hemodialysis

71
Q

which of following is not a characteristic symptom of DNP intoxication? a. fever b. dyspnoe c. lung edema d. hypertension e. cyanosis

A

d. hypertension

72
Q

which of the following states isn not true. a. b. c. lead poisoning may result in obesity. d. e.

A

c. lead poisoning may result in obesity.

73
Q

Which of the following does not induce acute hypoxia? a. chlorates b. cyanide c. nitrites d. CO e. benzene

A

c. nitrites

74
Q

which of the followings does not induce acute hypoxia? a. chlorates b. cyanide c. nitrites d. CO e. benzene

A

c. nitrites

Toxicology (20 decks)

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