Written Exam One Q61 - Q90 Flashcards
1
Q
61. An immunoglobulin-secreting plasma cell is developmentally most closely related to a A. B lymphocyte B. fibroblast C. mast cell D. colony-forming cell E. T lymphocyte
A
A. B lymphocyte
2
Q
- Which of the following statements best characterizes macrophages?
A. They are easily distinguished from fibroblasts in routine histologic slides
B. They contain phosphatases, esterases, and proteases that digest
phagocytized material
C. They can readily digest carbon, cellulose, asbestos, and tubercle bacilli
D. They originate from granulocytes that leave the circulation to divide and
differentiate
E. They are essential in wound healing because they secrete newly formed
collagen
A
B. They contain phosphatases, esterases, and proteases that digest
phagocytized material
3
Q
- Which of the following descriptions best characterizes the connective tissue-epithelial interface?
A. A basal lamina, formed in part by a nonfibrillar collagen, separates the two basic tissue types
B. Hemidesmosomes may be observed between the epithelial cells and the underlying fibroblasts
C. A basement membrane consisting of fibroblasts surrounded by a basal lamina forms a continuous sheet between the two tissues
D. Tight junctions join the basal epithelial cells to collagen fibers in the underlying connective tissue
E. A basal lamina establishes an impermeable barrier to movement of materials between the two tissues
A
A. A basal lamina, formed in part by a nonfibrillar collagen, separates the two basic tissue types
4
Q
- Which of the following statements regarding a cell synthesizing fibrillar
collagen is most accurate?
A. Its cytologic characteristics are those of a fibroblast
B. It incorporates glycine and hydroxyproline at a high rate from the
extracellular space
C. It stores collagen fibrils in secretory vacuoles in the cytoplasm
D. It does not synthesize any other component of the extracellular matrix
E. It is a terminally differentiated cell
A
A. Its cytologic characteristics are those of a fibroblast
5
Q
- Which of the following statements best describes proteoglycans (PGs)
of the connective tissue extracellular matrix?
A. They are large proteins with small polysaccharide side chains
B. They are one of the fibrous components of the extracellular matrix
C. They are identical to glycoproteins of the extracellular matrix
D. They consist of multiple large polysaccharides attached to a protein core
E. They are made up exclusively of repeating units of glucose and galactose
A
D. They consist of multiple large polysaccharides attached to a protein core
6
Q
66. The presence or absence of which one of the following structures or secretions can be used to distinguish blood basophils and connective tissue mast cells? A. Histamine B. Basal lamina C. Heparin D. Cytoplasmic granules E. Lobulated or oval nucleus
A
E. Lobulated or oval nucleus
7
Q
- All of the following statements concerning connective tissue are correct EXCEPT
A. a general characteristic of connective tissue is an extensive extracellular space
B. connective tissue may be classified as regular or irregular based on the arrangement of collagen fibers
C. complex intercellular junctions between fibroblasts separate connective tissue from the other basic tissues
D. one component of connective tissue is extracellular fibers that have cross-striations not visible with light microscopy
E. macrophages, mast cells, fibroblasts, adipose cells, and undifferentiated mesenchymal cells constitute the resident cell population
A
C. complex intercellular junctions between fibroblasts separate connective tissue from the other basic tissues
8
Q
- All of the following statements concerning collagen are correct EXCEPT
A. it is a family of related glycoproteins
B. it is a major component of the cytoskeleton
C. it is not synthesized correctly in the absence of vitaminC
D. it is synthesized by fibroblasts, epithelial cells, and muscle cells
E. it has a tensile strength that approximates that of steel
A
B. it is a major component of the cytoskeleton
9
Q
- All of the following statements about collagen are correct EXCEPT
A. it is rich in hydroxyproline and hydroxylysine
B. it is rich in glycine
C. it has a triple-helical configuration
D. it is rich in sulfur-containing amino acids
E. it has an extremely high tensile strength in its fibrous form
A
D. it is rich in sulfur-containing amino acids
10
Q
70. Which glycoprotein organizes elastin into fibers? A. fibronectin B. laminin C. fibrillin D. collagen VII E. integrin
A
C. fibrillin
11
Q
- Consider the receptor for fibronectin. Which of the following is TRUE?
A. Found only within the lamina densa of the basal lamina
B. A cross-shaped glycoprotein
C. Links the cytoskeleton inside of the cell with the extracellular matrix outside of the cell
D. A member of the cadherin protein family
E. Component of the zonula adherens of epithelial cells
A
C. Links the cytoskeleton inside of the cell with the extracellular matrix outside of the cell
12
Q
- Which of the following is TRUE concerning hyaluronic acid?
A. a component o elastic fibers
B. a glycosaminoglycan
C. a proteoglycan with a shape resembling a bottle brush
D. highly sulfated
E. a small molecule
A
B. a glycosaminoglycan
13
Q
- Which of the following events in collagen synthesis occurs outside of the
cell?
A. synthesis of preprocollagen
B. hydroxylation of lysine residues
C. triple-helix formation
D. carbohydrate addition to procollagen
E. cleavage of procollagen by procollagen peptidases
A
E. cleavage of procollagen by procollagen peptidases
14
Q
- Scurvy, due to a deficiency of vitamin C, is characterized by impaired wound healing, bone formation and loosening of teeth in their sockets. This is because vitamin C is an essential co-factor for:
A. cleavage of the amino-terminal signal sequence from preprocollagen
B. hydroxylation of proline and lysine residues in procollagen within the rER
C. glycosylation of specific hydroxylysine residues in procollagen within the rER
D. formation of a triple helix by three α procollagen chains
E. None of the above is true.
A
B. hydroxylation of proline and lysine residues in procollagen within the rER
15
Q
75. Which of the following cells are capable of synthesizing elastic fibers? I. fibroblasts II. arterial smooth muscle cells III. chondroblasts / chondrocytes IV. adipocytes
A. I, II, and III only B. I and III only C. II and IV only D. IV only E. None of the above
A
A. I, II, and III only
