Wounds Flashcards

1
Q

Mecahnical injuries

A

By far most common

Grazes, abrasions, erosions – heal relatively quickly by mitotic division and migration of underlying intact basal epithelium. Minimal involvement of inflammatory cells, capilleries etc.

Bruising, hematomas, contusions (=bruise + skin injury)

Puncture/penetrating wounds

Lacerations/incised wounds

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2
Q

Thermal injuries

A

Rare

Theramal burns

Friction rubs

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3
Q

Chemical injuries/irradiation

A

Rare

Acids - cause coagulation necrosis and protein precipitation

Alkalis - cause liquefaction necrosis

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4
Q

Clean wound

A

Elective/Surgical wounds created under aseptic conditions, primarily closed.

No break in technique or dirty space entered (i.e. respiratory, GI, UG)

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5
Q

Clean contaminated wound

A

GI, respiratory or UG tract (without urinary infection) entered without significant contamination.

Or minor break in aseptic technique

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6
Q

Contaminated wound

A

Traumatic wounds = always contaminated.

Or elective procedure with major break in aseptic technique

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7
Q

Dirty wound

A

> 1x10^5 bacteria.

Traumatic wound with devitalized tissues, FB, feces, chronic wound.

Transection of clean tissues to get to dirty (i.e. abscess, sinus surgery with pus in sinus)

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8
Q

Stages of wound healing

A

Inflammatory/debridement: haemostasis/acute inflammation

Proliferative/repair: tissue formation

Maturation/remodelling: tissue strengthens

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9
Q

Inflammatory/Debridement: hemostasis/acute inflammation

A

Immediate, lasting days to weeks

Neutrophils: removed damaged tissue and chemo attractants

Macrophages: Release O2 free radials, cytokines, tissue growth factors (thus initiating proliferative phase)

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10
Q

Proliferative/Repair: tissue formation

A

Day 3-14++

Angiogenesis, fibrous and granulation tissue formation, collagen deposition, epithelialization, wound contraction

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11
Q

Maturation/Remodeling: tissue strengthens

A

14 days++

Ends in the formation of scar tissue 1 to 2 years later

remains 15% to 20% weaker than the original tissue

Collagen fibers, which were once haphazardly arranged, are reestablished in bundles, cross-linked, and aligned along lines of tension by fibroblasts to progressively increase the tensile strength.

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12
Q

Most important history to check after a wound

A

Tetatnus status of the horse

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13
Q

How much blood can a horse loose without concern

A

A 500kg horse can lose up to 5 L without too much concern

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14
Q

How to control haemorrhage from superficial vessels

A

Tight pressure bandage for around 20 minutes

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15
Q

Surgical haemostasis

A

Applying a haemostat to the vessel

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16
Q

Topical agents for haemostasis

A

often expensive.

Include fibrin adhesives, Chitosan-based dressings (Celox gauze or granules) calcium alginate products, oxidised cellulose or collagen sponges (all of which provide a substrate for clot formation) and cyanoacrylate adhesives (e.g. vet-bond).

Most are suitable for surface use only.

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17
Q

What should you not use on the open wound surface?

A

Anti-septics that contain soap on the open wound surface

Hydrogen peroxide

Hypochloride

Salicylic or aceetic acid

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18
Q

What should you use for wound lavage?

A

Warm isotonic fluids

Povidine iodine solution

Chlorhexidine

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19
Q

Aseptic synoviocentesis

A

Mandatory to assess synovial structure involvement, provided that iatrogenic contamination can be avoided. i.e. don’t pass a needle directly through the wound to access the joint, access the joint from another point e.g. if the wound is on the medial fetlock, tap the joint from the lateral side.

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20
Q

Heel bulb laceration

A

Common injury (‘over-reach’)

ID structures involved (rule out coffin joint, DDFT, and navicular bursa involvement)

Primary or delayed primary closure best

Hoof cast reduces movement to allow faster healing and better comfort - Easy to apply, Horse must be box rested

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21
Q

Coronary band laceration

A

If deep can affect coffin joint/DFTS

Suture if possible to prevent healing with the CB misaligned -> hoof wall defects

Hoof cast also good

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22
Q

Eyelid injuries

A

Must be sutured to prevent deformities -> problems with tear distribution and secondary ulceration

Even if contaminated, usually heal primarily

Check globe and orbit

Close with small gauge suture material - keep knots away from cornea

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23
Q

Axilla injuries

A

Stake injuries common

Pneumomediastinum (+/- pneumothorax) can occur due to air being pumped up when foreleg moves

Box rest may prevent this

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24
Q

Thorax injuries

A

Check for rib fracture + pleural penetration (digital exploration will tell you a lot)

If pleural penetration, can hear air being sucked in or horse in respiratory distress; radiographs

Usually a referral case - the collapsed lung plugs mediastinum so horse can usually breath with unaffected lung while travelling

Emergency chest drain?
§ Chest tube/teat cannula with 60ml syringe and 3 way stop clock to evacuate air
§ Place in upper 1/3 chest - safest
Broad spectrum antibiotics

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25
Abdomen injuries
Careful palpation will often help to decide whether abdominal wall has been fully penetrated Abdominocentesis can help but changes take several hours (esp if a small penetration) Often just monitor for CS of peritonitis e.g. colic, pyrexia, high HR If large wound and risk evisceration, plug hole with damp gamgee pads and wrap with belly bandage before referral
26
Flexor tendon lacerations of the lower limb
If referring a horse with a tendon laceration, splinting of the leg (dorsal cortices aligned) and broad spectrum antibiosis are indicated prior to transport. Postoperative external coaption for a prolonged period is likely to be involved in the treatment after surgical repair
27
Extensor tendon lacerations
in the absence of synovial sepsis of the extensor tendon sheath are frequently managed without primary surgical repair of the tendon. Splinting should be applied for the first few days until the animal learns to accommodate for its gait deficit.
28
Radiographs of wounds
Fractures Foot penetrations - radiograph with nail still in place Osteomyelitis - old wounds Foreign bodies - if radiopaque Gas opacity to determine if wounds tracking near joints or bon
29
Ultrasound of wounds
Gas opacity from wound often inhibits use, but occasionally useful Soft tissue damage - i.e. wound over flexor tendon Foreign bodies Gas opacity to determine if wounds tracking near joints or bones
30
Primary closure of wounds
Clean wounds with minimal contamination are good candidates. Will give fastest healing time + best cosmetic result. Partial closure can be used for large wounds and often speeds healing whilst allowing drainage. Necrotic tissue should be debrided. Upwards pointing 'V' skin flap often poorly vascularised, even if it subsequently dies it acts as a biological dressing - like a full thickness skin graft. If wound edges are under tension, tension relieving suture patterns e.g. vertical or horizontal mattress or cruciates should be used. Stent-supported sutures provide extra tension relief of the wound margin but not often needed. Immobilisation with a bandage cast or splint will also help to stabilise the suture line in wounds that are closed under tension. Degloving wound has good primary closure: proximal limb bandage placed to protect flap during transport.
31
Best suture material for equine wounds
Polypropylene is the least reactive suture material available and is therefore the best for equine skin, but other synthetic materials are also suitable (nylon, PDS).
32
Standing repair or GA
fractious horse, ££, other structures involved e.g. joints
33
In field or referral repair
your experience and comfort level, suspected/confirmed synovial sepsis/fracture etc., complexity of repair AND aftercare.
34
Delayed primary closure
up to 5 days after the injury a good option for contaminated wounds which are unsuitable for closure at the first visit. Skin retraction usually occurs making it difficult to completely close wound.
35
Delayed secondary closure
(after 5 days post injury i.e. after granulation tissue formed) rarely used apart from certain areas e.g. heel bulbs– often skin is adherent to underlying granulation bed. Granulation tissue is cut back and the skin is reapposed where possible. Skin retraction occurs as above.
36
Second intention healing
very common - for all contaminated wounds or if large amounts of tissue loss/devitalised tissue. Heals primarily by proliferative/repair phase of wound healing – granulation then epithelisation and contraction. Exudate is common and NORMAL. Wound is usually bandaged during secondary intention healing (unless site is difficult to bandage .e.g. head, upper body)
37
Topical medications for secondary intention healing
Hydrogel preparations Silver sulfadiazine (gram negative bacteria and pseudomonas, contraindicated in pregnant animals) Topical antibiotics: aminoglycoside (gram negative), soluble antibiotics lie penicillin, gentamycin etc. Caustic agents (none proven to work) Corticosteroids (reduces granulation tissue) Manuka honey (contaminated/devitalised/non-healing wounds)
38
Primary layer of a bandage
Adherent or non-adherent dressing
39
Adherent dressing
these dressings stick to the wound surface and thus debride the surface when removed – often painful to remove – e.g. wet to dry swabs. Not used much these days.
40
Non-adeherent dressings
Cotton cellophane (melonin) Polyurethane foam (advasorb, allevyn, biatain) Polyurethane sheet (opsite) Hydrocolloids (Tegasorb, replicare) Petroleum impregnated gauze (vaseline) Calcium alginate (algisate, algiderm) Activated charcoal
41
Cotton cellophane
Melolin Cotton, coated with perforated polyethylene which is non-adherant. Not very absorptive but when removed -> minimal trauma to the wound surface.
42
Polyurethane foam dressings
Advasorb, Allevyn, Biatain waterproof but gas permeable. More absorptive than cotton cellophane and ideal for use with a hydrogel.
43
Polyurethane sheet dressings
Opsite Transparent adhesive film which is semi-occlusive, allowing passage of gases but not fluid. Very little capacity for absorption therefore maintain a moist wound environment and promote epithelisation of partial thickness wounds or incisions which can not be easily bandanged e.g. on rump or thorax.
44
Hydrocolloids
Tegasorb, Replicare contain gel-forming agents, such as sodium carboxymethylcellulose (NaCMC) and gelatin. In many products, these are combined with elastomers and adhesives and applied to a carrier - usually polyurethane foam or film, to form an absorbent, self adhesive, waterproof wafer. Hydrocolloids absorb liquid and form a gel, which may be cohesive. Expensive and do not stick to haired skin.
45
Petroleum impregnated gauze
Vaseline These allow passage of exudates into the secondary layer of the bandage. May have antibiotics included in the dressing. Innert and non-irritating but slow the rate of re-epithelisation.
46
Calcium alginate dressings
Algisite, Algiderm has haemostatic properties and is highly absorbent therefore suitable for exudative wounds. Should not be used on dry wounds as will dessicate the site.
47
Activated charcoal
designed primarily to control odour and absorb bacteria (especially burns patients). Reported to have an inhibitory effect on granulation tissue.
48
Compressive layer of bandage
Cotton wool/gamgee with a stretchy woven bandage on top Can repeat the compressive layer several times -> more immobilisation, stabilisation and absorbtion if wound v exudative
49
Protective layer of a bandage
Vet wrap , Elastoplast top and bottom
50
Complications of wound healing
Infection/contamination Excess tension on suture line Loss of blood supply Dead space (poor drainage) Excessive motion
51
Clinical signs of wound infection
Discolored granulation tissue Oedema in and around the wound Purulent exudate Odor Increased lameness and pain on palpation around the wound
52
What to do if you get dead space in a wound
if large dead space when closing wound then use a drain. ○ Penrose drain most common in 1st opinion practice. Prevent skin scalding at drainage site - vaseline ○ Mesh the skin to allow drainage, pressure bandage - only for areas where will not compress important structure like the flexor tendons
53
Causes of non-healing, chronic wounds - locally
Infection/necrotic tissue Tension/motion Poor vascular supply Exuberent granulation tissue Foreign body Sequestrum Large skin defect
54
Definition of wound infection
>10^5 bacteria/gram of tissue
55
Exuberent granulation tissue
'proud flesh' Limbs >> trunk wounds, Horses >> ponies Once granulation tissue protrudes higher than wound edge, v. difficult for epithelium to grow over it Due to inefficient acute inflammatory phase and protracted chronic inflammatory response -> too much granulation tissue produced
56
Factors that predispose to proud flesh
Chronic inflammation ◊ Infection - common cause Motion Bandages and casts Size of horse
57
Treatment of exuberent granulation tissue
Use treatments for excess motion, infection etc. as appropriate plus ◊ Bandage with moderate pressure ◊ Topical steroids Excision of excess granulation tissue ◊ Can usually be done with sedation + local anaesthesia ◊ Bleeds a lot - cut from distal to proximal
58
Sequestrum
due to exposed desiccated bone – may have lost some periosteum in original injury Initial injury traumatises bone or blood supply to bone (periosteum stripped) Stripping of periosteum + loss of blood supply -> necrosis of superficial bone -> walled off from the healthy intact bone Suspect when see mature granulation bed but with a cleft or draining tract ('cloaca') Take radiographs
59
Causes of non-healing, chronic wounds - systemically
Has to be quite severe to affect wound healing PPID (high endogenous cortisol) Protein/nutrient deficient
60
Involucrum
Reactive bone forms around the necrotic portion
61
Cloaca
Draining tract to the skin connects with an opening to the sequestrum
62
Indications for skin grafting
Too large (to suture or heal by secondary intention) Slow healing
63
Two basic types of skin graft
Pedicle graft - vasular and nerve supply Free graft - devoid of vascular and nerve supply, full thickness or split thickness
64
Island grafts - pinch/punch grafts
Most common type of grafting in horses Purpose is to increase area of epidermis from which epithelization proceeds Implanting grafts in the granulation bed, rather than applying them to surface, is better Punch: full-thickness plugs of skin harvested with skin biopsy tool, and implanted into granulation tissue using another skin biopsy tool, one size smaller Pinch: small discs of skin harvested by hand using scalpel blade Elevate skin with hypodermic needle with bent tip
65
Donor sites for island grafts
Neck beneath mane Ventral abdomen (thick skin here) Perineum
66
Tunnel grafts
Useful for large skin defects § Highly mobile sites § Sites that are difficult to bandage □ Thorax/abdomen/gluteal Technically simple Donor site = neck, leaves more of a scar than pinch/punch
67
Split thickness grafts
Very painful to harvest Needs specialist equipment (dermatome) Technically difficult but higher % 'take'
68
Disadvantages of full thickness sheet grafting
Not accepted as readily as split-thickness grafts □ Have fewer exposed vessels available for imbibition or inosculation □ Requirement for nourishment is greater Epidermis usually sloughs
69
Synovial sepsis
potentially fatal in horses and must be treated as an emergency. Survival rate (to discharge from hospital)= 89% , return to previous athletic function = 69% If synovial contamination has occurred, immediate parental antibiotics (penicillin + gentamicin) should be administered and the horse should be for arthroscopic lavage under general anaesthesia.
70
Where can synovial sepsis occur?
Joints Tendon sheaths – lower rate of return to athletic function -circa 50% Bursae
71
What is synovial sepsis caused by?
Traumatic wound (most common) Iatrogenic i.e. after joint injection (or inadvertent puncture of joint during nerve block) or after joint surgery (arthroscopy) Haematogenous (rare in adult horse, common in foal)
72
Pathophysiology of synovial sepsis
Contamination of synovial cavity Marked inflammatory response = marked lameness § Fibrin accumulates + bacteria + inflammatory cells -> synovial thickening/pannus § Continues inflammatory process may lead to irreversible articular cartilage, tendon and/or subchondral bone damage/infection
73
Aetiologies of synovial sepsis
Penetrating traumatic injury - most common in adults Haematogenous spread - most common in foals Iatrogenic infection Extension of local infection
74
Clinical signs of synovial sepsis
Lameness typically acute and severe Open joints/acute wounds with synovial involvement may initially be mildly/not lame Osteomyelitis in foals may present first with mild, intermittent lameness Synovial effusion and/or periarticular oedema TPR ○ Adults typically WNL ○ Foals typically febrile, but not always
75
DIagnosis of synovial sepsis
Synoviocentesis § Collection of synovial fluid § Number 1 test for diagnosis no matter the aetiology § Fluid analysis (gross and microscopic) – WBC count, % of neutrophils and TP most important § Culture and sensitivity – takes days to get result – often not performed Synovial distension/pressure leak test § Sterile saline injected into joint under pressure to see if any communication present with wound § Always collect joint fluid if possible before distending joint
76
Synoviocentesis technique
Aseptic prep Aseptic technique using landmarks to enter Collection/aspiration of synovial fluid (for analysis and C/S) If wound present enter at a different site and do leak test
77
Normal synovial fluid
straw yellow, translucent, viscous WBC: <10 x 109/L, Total Protein: <10 g/L, usually <15% neutrophils, but can increase after e.g. joint injection up to 50-60%
78
Septic synovial fluid
Varies (Florescent yellow-cream coloured, serosanguinous), turbid or flocculent material, decreased viscosity WBC: >20 x 109/L , Total Protein: >30 g/L >90% neutrophils
79
Treatment of synovial sepsis
Rapid (ideally <24hrs) and aggressive Synovial lavage Antibiotics (penicillin and gentamycin systemically, Aminoglycosides locally) Additional treatments e.g. stall rest, NSAIDs, bandaging
80
Prognosis of synovial sepsis
Good for vast majority of horses with prompt treatment (<24 hrs) Excellent for survival (90%) Good for athletic use (50-70% reported—lower with foals) Prognosis decreases with: ○ increased time from inoculation to lavage ○ degree of damage to sheath /joint, surrounding structures, or infection into the bone ○ Specific synovial structures known to have worse outcomes than others OA is a sequellae to septic arthritis—especially if prolonged treatment