Wound Healing Flashcards
cotinine
alkaloid metabolite of nicotine
hydrogen cyanide
inhibits oxygen transport and oxidative metabolism
cutis laxa
inherited or acquired connective tissue disorder; alteration in elastin quantity of morphology
ehler-s danlos syndrome
genetic defect in collagen and connective tissue synthesis and structure; can affect skin, joints and vessels
osteogenesis imperfecta
congenital bone fragility due to genetic mutations of type I procollagen
phases of wound healing
Inflammatory phase: day 0-3 -hemostasis and inflammation -chemotaxis and activation Proliferation phase: day 4-14 -epithelialization -angiogenesis -granulation tissue formation -collagen deposition Maturation/Remodeling: day 8-1 year -type III collagen replaced by type I -deposition of collagen in organized network
wound strength
3% at 1 week
30% at 3 weeks
80% at 3 months
growth factors
TGF beta-deposition of extracellular matrix
PDGF-chemotaxis
FGF & EGF-epithelialization
VEGF - angiogenesis
cytoprotective agents to help reduce radiation effects
amifostine
epoetin-alpha
pentoxifylline
adipose and mesenchymal derived stem cells
Vitamins
A: increase monocytes and macrophages to wound beds, simulate fibrosis, increase collagen synthesis, improved epithelialization, counteract steroid effects
C: collagen synthesis, improves neutrophil function, increases neutrophil function and angiogenesis
E: antioxidant, anti-inflammatory, inhibits collagen synthesis, decreases wound tensile strength
Zinc: cellular growth and replication
VAC sponges
most effective intermittent 125mmHg
black: polyurethane, pores 400-600
most effective to stimulate granulation tissue, wound contraction and edema reduction
white: poly-vinyl-alcohol: hydrophilic and smaller pores
silver: antimicrobial activity
