Wound Healing Flashcards
What are the 3 goals of tissue response to injury?
Stop blood loss
Remove and repair damaged tissue
Restore function
What are the 7 phases of wound healing?
- Hemostasis
- Inflammation
- Debridement
- Proliferation
- Repair
- Remodeling
- Maturation
The phases of wound healing can be broken down into 3 phases, what are they?
Phase I : hemostasis, inflammation, and debridement
Phase II : proliferation and repair
Phase III : remodeling and maturation
How many days are each of the phases in wound healing?
Phase I : Days 1-4
Phase II : Days 4-21
Phases III : Day 21 - 2 years
In what phase of the wound healing process would you see granulation, contraction, and epithelialization?
Phase II : proliferation & repair phase
Which cell type(s) are involved in hemostasis and inflammation?
Platelets
Which cell type(s) are involved in debridement?
Neutrophils
Which cell type(s) are involved in repair (proliferation & granulation)?
Macrophages
Lymphocytes
Angiocytes
Neurocytes
Which cell type(s) are involved in repair (contraction & epithelialization)?
Fibroblasts
Keratinocytes
Which cell type(s) are involved in remodeling/maturation?
Fibrocytes
What are the functions of neutrophils?
Destroy bacteria
Enzymes remove damaged tissue
What are the functions of platelets?
Aggregate-clot formation
Produce growth factors to influence healing
What are the functions of monocytes?
Phagocytize necrotic tissue
Release cytokines and growth factors in influence healing
Which cytokines/growth factors do monocytes release?
TNF alpha
IL-1 Beta
IL-6
