wound healing Flashcards
what are the stages of wound healing
hemostasis
inflammatory
proliferative
remodelling
what are the causes of inflammations
trauma
diseases
invading pathogens
allergic reactions
characteristics of acute inflammation
redness
warmth
swelling
loss of function
pain
it occurs upon injury
stopping bleeding
vascular constrictions
hemostasis which takes about an hour
what is the most important cellular component
platelets which responsible for forming clot and adhere to exposed collagens
what causes pro inflammatory and growth factors releases
clot and wound tissue
what are the growth factors
transforming
platelets derive
fibroblast
epidermis
movement of fluid from vessels into extracellular space known as
extravasation which leads to continuation of edema formation on inflammatory phase
characteristics of inflammatory phase
characterized by infiltration of neutrophils
macrophages
lymphocytes
which phase is perceived as negative, but a healthy success of the phase is critical for success wound healing
inflammatory phase
influx of phagocytic cells and proteins occurs for later stage of healing occurs in which phase
proliferation phase
what are the major components of extracellular matrix
collagen
elastin glycosaminoglycans
proteoglycans
what happens in remodeling phase
=rearrangement of newly formed collagen matrix
=gaining of tensile strength
=regression of many newly formed capillaries
=longest phase about 1 yr.
what are the classes of chronic wounds
vascular ulcers
diabetic ulcers
pressure ulcers
what are the categories of factors affecting wound healing
local which include
=oxygenation
=infection
=foreign body
=venous sufficiency
systematic which includes
=age and gender
=sex hormones
=stress
=ischemia
=diseases
=obesity
=medications
=alcoholism and smoking
=immunocompromise
=nutrition
