Workshop 6 Concepts

Question 1

Normal Dose Dependent Parameters

Answer 1

• Cmax
• AUC
• Css

*every other is not!

Question 2

Non-Linear PK

Answer 2

• When there is a change in any of the other parameters with dose or time

Question 3

Non-Linearity with dose occurs when…

Answer 3

• One or more processes in abs/dis/elim become saturated

Question 4

Saturable Processes

Answer 4

Absorption
- solubility, active transporter, efflux transporter

Distribution
- Fu and FuT

Elimation

• Renal: Fu (in Fu*GFR), secretion, reabsorption
• Hepatic: Fub, CLint

Question 5

With INHIBITOR (or auto-inhibition)

Answer 5

CLint will DECREASE

Question 6

With INDUCER (or auto-induction)

Answer 6

CLint will INCREASE

Question 7

If case is increasing clearance (bc of higher dose/infusion rate), possible mechanisms are

Answer 7

• Saturable plasma protein binding
• Saturable tubular reabsorption
• Auto-induction

Question 8

WITH TIME in normal linear PK…

Answer 8

• AUC (from 0toinf) after SD will equal AUC from (0totau) after MD
• IF DIFFERENT = non-linear

Question 9

If a drug has LOW fe and not eliminated renally, possible mechanisms are

Answer 9

IF Cl is decreasing..

• saturation of hepatic metabolism
• auto inhibition

If low fe than CANNOT be secretion sat
If given IV CANNOT be sat first pass metabolism

Question 10

If C(0)&raquo_space;» Km

Answer 10

ZERO order kinetics