Missing Equations

Question 1

Cu =

Answer 1

A/Vu = A / (V/fu)

Question 2

% in body within plasma =

Answer 2

(Vp * C) / (V * C)

• Vp always 3L

Question 3

L1, lambda1 vs L2, lambda2

Answer 3

L1 is the y intercept of the NEW line you create from doing C - Chat. Lambda1 is “Ka”, abs. rate constant, (slope of new line)

L2 is the y intercept of the line you extrapolate from elimination part of graph. Lambda2 is “K”, elim. rate constant, (terminal slope of graph)

Lambda 1 should always be&raquo_space;> lambda 2

Question 4

To find slope of K / Lambda

Answer 4

• Y portion is a log scale, X portion is normal scale

= - ln (y2/y1) / (x2-x1)

Question 5

Volumes

Answer 5

V1 «< Vss «< V2

Question 6

Physiological Volumes

Answer 6

Plasma (Vp) = 3.5

Extracellular water = 14

Intracellular water = 28

Total body water = 42

Question 7

Approx. half-lives to reach steady state?

Answer 7

~ 3

Question 8

Normal Q (h,b) value!

Answer 8

*use when not given Q (like to find if High E or Low E drug)

= 80 L/hr or 1350 ml/min

Question 9

How to find if High E or Low E drug

Answer 9

1. Find CL(h) = (1-fe)*CLtotal
2. Find CL (h,b) = CL(h) * C/Cb
3. Find E(h,b) = CL(h,b) / Q -> (on eq sheet)

• If < 0.3 then LOW E
• If > 0.7 then HIGH E