Binding Plasma Proteins

Question 1

Albumin

Answer 1

Average Concentration: 0.6 mM

Generally binds ACIDS

Question 2

alpha-1-acid glycoprotein

Answer 2

Average Concentration: 0.015 mM

Generally binds BASES

Question 3

Lipoproteins

Answer 3

Average Concentration: Variable

Generally binds NEUTRAL lipophilic compounds

Question 4

TWO EXTREMES

Answer 4

LOW E (cl) is < 0.3

HIGH E (cl) is > 0.7

Question 5

Is drug Low E or High E?

Answer 5

• Compare blood clearance (CLb) to hepatic blood flow (Q)

- 100 ml/min is obvi LOW and 1200 ml/min is obvi HIGH