Workshop 2 Flashcards
What are three drugs that have physical withdrawal?
Alcohol
Benzodiazepines
Opiates
What are the serious withdrawal symptoms?
Seizures -> high risk of death.
Agitation, confusion (alcohol).
Tremors, vomiting, abdominal pain, flu-like symptoms etc.
How risky is opiate withdrawal?
If the patient is otherwise well, the risk of death is small. If in older patients there is a higher risk of CV complications: MI.
Why does withdrawal sometimes last a long time?
It can take a very long time to restore the neurotransmitter imbalance.
Also some changes (receptor plasticity) might last longer.
Why can opiate withdrawal be particularly painful?
Opiate use/withdrawal causes changes in the pain pathway - heightened perceptions of pain and craving.
What % of people in drug and alcohol misue have a mental health disorder?
75%, what comes first?
Cannabis and alcohol withdrawal can cause acute ________ and ________ respectively.
Cannabis and alcohol withdrawal can cause acute psychosis and anxiety respectively.
What does substitution therapy for opiates consist of?
Methadone and buprenorphine licensed for SL/wafer although a lot can be lost via first pass.
What is HAT?
Heroin associated injection therapy. Diamorphine injections.
What is chlordiazepoxide?
BZ used in alcohol withdrawal; substitution and then withdrawal.
Long term high dose BZ use causes
Can cause cognitive impairment (>30mg OD for diazepam).
Why must patients sign up and agree to the risks of BZ substitution therapy?
Known to cause cognitive impairment if >30mg OD for diazepam.
Aversion therapy for alcohol consists of
Disulfiram
Mechanism of action of disulfiram
Inhibitor of acetaldehyde dehydrogenase enzyme which causes the effects of a hangover to be felt immediately.
What is the cycle of change?
- Pre-contemplation
- Contemplation
- Planning/preparation
- Action
- Maintenance