SMH

Question 1

What is the pharmacology of buprenorphine?

Answer 1

MOR partial agonist
Long duration of action
Antagonise effects of subsequently administered opioids.

KOR antagonist
ORL-1 agonist/NOP agonist

Question 2

What is BU10119?

Answer 2

Kappa and mu antagonist
MOP partial agonist

Antidepressant like activity in novelty-induced hypophagia task

Antidepressant like activity in the forced swim task

Inhibits drug and stress induced relapse to drug taking.