Women's Health Med Review

Question 1

Estradiol Trade Name

Answer 1

Estrace (oral)

Question 2

Estradiol Category

Answer 2

Oral Estrogen Derivative

Question 3

Estradiol Use

Answer 3

Menopause

Question 4

Estradiol Dose

Answer 4

0.5-1 mg PO qday

Question 5

Estradiol AE

Answer 5

Common: Nausea, headache, bloating, breast tenderness, bleeding

Serious: CHD, stroke, VTE, breast CA, gallbladder disease

CI: Hx of/active thromboembolic disease; breast cancer or estrogen-dependent neoplasm; pregnancy; liver disease, undiagnosed vaginal bleeding; prevention of treatment of cardiovascular disease, cerebrovascular disease, or dementia

Preg Cat: X

Question 6

Medroxyprogesterone Acetate (MPA) Trade Name

Answer 6

Provera

Question 7

Medroxyprogesterone Acetate Category

Answer 7

Oral Progestrogen; Contraceptive

Question 8

Medroxyprogesterone Acetate Use

Answer 8

Menopause

Question 9

Medroxyprogesterone Acetate Dose

Answer 9

2.5-10 mg PO qday

Question 10

Medroxyprogesterone Acetate AE

Answer 10

Common: nausea, headache, weight gain, bleeding, irritability, depression

Serious: VTE, decreased BMD; may cause increased risk of breast cancer when used continuously with estrogen

CI: Hx of/active thromboembolic disease; breast cancer or estrogen-dependent neoplasm; pregnancy; liver disease, undiagnosed vaginal bleeding; prevention of treatment of cardiovascular disease, cerebrovascular disease, or dementia

Preg Cat: X

Question 11

Estradiol Transdermal Trade Name

Answer 11

Alora, Climara, Estraderm, Vivelle, Vivelle Dot

Question 12

Estradiol Transdermal Category

Answer 12

Transdermal estrogen

Question 13

Estradiol Transdermal Use

Answer 13

Menopause

Question 14

Estradiol Transdermal Dose

Answer 14

0.025-0.05 mg patch, changed weekly (Climara) or changed twice weekly

Question 15

Estradiol Transdermal AE

Answer 15

Common: Nausea, headache, bloating, breast tenderness, bleeding

Serious: CHD, stroke, VTE, breast CA, gallbladder disease

CI: Hx of/active thromboembolic disease; breast cancer or estrogen-dependent neoplasm; pregnancy; liver disease, undiagnosed vaginal bleeding; prevention of treatment of cardiovascular disease, cerebrovascular disease, or dementia

Preg Cat: X

Question 16

Estradiol + Norethidrone Transdermal Trade Name

Answer 16

CombiPatch

Question 17

Estradiol + Norethidrone Transdermal Category

Answer 17

Combination Transdermal Estrogen/Progestogen

Question 18

Estradiol + Norethidrone Transdermal Use

Answer 18

Menopause

Question 19

Estradiol + Norethidrone Transdermal Dose

Answer 19

0.05/0.14 - 0.05/0.25 mg per 24 hours; apply one patch twice weekly

Question 20

Estradiol + Norethidrone Transdermal AE

Answer 20

ESTROGEN:
Common: Nausea, headache, bloating, breast tenderness, bleeding

Serious: CHD, stroke, VTE, breast CA, gallbladder disease

PROGESTOGEN:
Common: nausea, headache, weight gain, bleeding, irritability, depression

Serious: VTE, decreased BMD; may cause increased risk of breast cancer when used continuously with estrogen

CONTRAINDICATIONS:
Hx of/active thromboembolic disease; breast cancer or estrogen-dependent neoplasm; pregnancy; liver disease, undiagnosed vaginal bleeding; prevention of treatment of cardiovascular disease, cerebrovascular disease, or dementia

Preg Cat: X

Question 21

Norgestimate/Ethinyl Estradiol (EE) Trade Name

Answer 21

Sprintec

Question 22

Norgestimate/Ethinyl Estradiol Category

Answer 22

Combination Oral Contraceptive (COC); Monophasic w/IM estrogen

Question 23

Norgestimate/Ethinyl Estradiol Use

Answer 23

Contraception

Question 24

Norgestimate/Ethinyl Estradiol Dose

Answer 24

0.25mg/35mcg PO qday

Question 25

Norgestimate/Ethinyl Estradiol AE

Answer 25

AE: Increased risk thromboembolism and stroke; may elevate BP; estrogenic and progestin side effects (nausea, breast tenderness, melasma, headache, breakthrough bleding, increased spotting, hypomenorrhea, fatigue, mood changes, increased appetite, weight gain, acne, oily skin, hirsutism, increased LDL, decreased HDL) CI: Absolute: Hx thromboembolic disease, stroke, CAD, breast cancer, estrogen-dependent neoplasm; undiagnosed abnormal uterine bleeding, hepatic tumors; pregnancy; heavy smokers >15 cigs/day over age 35; active liver disease; migraine HA with focal neuro sxs; postpartum during first 21 days as well as days 21-42 in women with additional TE risk factors

Question 26

Raloxifene Trade Name

Answer 26

Evista

Question 27

Raloxifine Category

Answer 27

2nd Generation Mixed Estrogen Agonist/Antagonist (MEAA)

Question 28

Raloxifine Use

Answer 28

Post-menopausal Osteoporosis (60mg PO qday)

Question 29

Raloxifine AE

Answer 29

Generally well tolerated; may cause leg cramps and hot flushes; risk for VTE similar to estrogens

Question 30

Alendronate Trade Name

Answer 30

Fosomax

Question 31

Alendronate Category

Answer 31

Bisphosphonate

Question 32

Alendronate Use

Answer 32

Prevention of post-menopausal (PM) osteoporosis; Osteoporosis; Glucocorticoid-induced osteoporosis

Question 33

Alendronate Dose

Answer 33

Prevention of PM osteoporosis: 5mg PO qday or 35mg PO qweek (Take after an overnight fast with a full glass of water while sitting or standing upright at least 30 minutes prior to morning meal; do not lie down for 30 minutes after administration; do not take with other meds or fluids; do not chew or suck on the tablet.) Osteoporosis: 10mg PO qday or 70mg PO qweek Steroid-induced: 10mg PO qday

Question 34

Alendronate AE

Answer 34

AE: Nausea; heartburn; GI pain; irritation; perforation; ulceration and/or bleeding; transient flu-like illness; muscle pains; possible risk of atypical femur fracture; possible slight increase in esophageal cancer; black box warning for rare osteonecrosis of the jaw; unproven risk of Afib. **Avoid when CrCl <35mL/min

Question 35

Calcium Carbonate Trade Name

Answer 35

Tums, Os-Cal, Caltrate, One-A-Day Women's MVI, Rolaids, Viactiv

Question 36

Calcium Carbonate Category

Answer 36

Calcium supplement

Question 37

Calcium Carbonate Use

Answer 37

Osteoporosis

Question 38

Calcium Carbonate Dose

Answer 38

1200-1500 mg PO qday elemental calcium divided into 500-600 mg doses during or after meals low in fiber to increase absorption

Question 39

Calcium Carbonate AE

Answer 39

AE: constipation; GI irritation; flatulance; rare kidney stones; increased Ca++

Question 40

Calcitonin Trade Name

Answer 40

Miacalcin

Question 41

Calcitonin Category

Answer 41

Calcitonin

Question 42

Calcitonin Use

Answer 42

PM Osteoporosis; Useful for painful compression fractures; Decrease corticosteriod-induced osteoporosis

Question 43

Calcitonin Dose

Answer 43

200 IU intranasal qday (nasal spray); Alternate nostrils on a daily basis

Question 44

Calcitonin AE

Answer 44

AE: May cause rhinitis, epistaxis, local irritation