Women's health 1 Flashcards
What are the features of premenstural syndrome?
- Occurs during luteal phase (high serum progesterone)
- 90% of women get it
- Psychological: irritable, tense, low mood
- Physical: breast tenderness, bloating, headaches
- Decrease in cognitive ability
Management of pre-menstrual syndrome?
- Keep a diary and journal
- Conservative: exercise
- Medical: COCP, SSRI for depression
What is menorrhagia?
- Heavy menstrual bleeding
- Defined as more than normal for that individual
What are the causes of menorrhagia?
PALM & COEIN
What are PALM & COEIN
- Polyps
- Adenomyosis
- Leiomyoma (fibroid)
- Malignancy & hyperplasia
& - Coagulation disorder
- Ovulatory (e.g. PCOS)
- Endometriosis
- Iatrogenic (COIL, POP, anticoagulation)
- No cause found (50%)
What are uterine fibroids?
- Uterine leiomyoma (benign smooth muscle tumour in myometrial layer)
- Monoclonal growth that is reactive to female sex hormones
- Common to have many, can vary in size, grey in colour
What is the epidemiology of uterine fibroids?
- 50% of women have them
- Increased risk in black women
- Worse perimenopause
- Pregnancy can worsen them or cause them to bleed (red degeneration)
What is the classification of uterine fibroids?
- Intramural (most common; inside myometrium)
- Subserosal (below peritoneum)
- Sub mucosal (beneath endometrium; these distort the cavity)
- Cervical
What are the features of uterine fibroids?
- Menorrhagia and cramps
- If very large can cause pressure effect (e.g. on bladder) and abdo pain/discomfort/bloating
- Endometrial distortion can cause infertility and miscarriage
- Rapid growth in pregnancy
Rapid fibroid growth not in pregnancy suggests what?
Sarcomatous change
Management of fibroids if wanting kids?
- TXA for heavy bleeding
- Surgery: myomectomy
Management of fibroids if not wanting kids?
- IUS (Mirena)
- Hysterectomy
What medications can be used pre-suregyt to shrink fibroids?
GnRH agonists (e.g. Leuprolide or gosereline)
What is the epidemiology of endometriosis?
- 40% of infertility due to endometriosis
- 80% of chronic pelvic pain due to endometriosis
- Ovary most common site (chocolate cyst; can rupture and cause lots of pain; increased risk of cancer)
RisK factors for endometriosis?
- Family history
- Oestrogen excess
Features of endometriosis?
- Menorrhagia, dysmenorrhoea, dyspareunia
- Subfertility
- Depression and fatigue
- Symptoms of tissue in the systems (e.g. dyschezia, urinary symptoms)
What is the investigation for endometriosis?
- Laparoscopic imaging and histology is diagnostic
- On exam: reduced motility with fixed retroverted uterus and pain on BM
- May have visible lesion on speculum (e.g. endometrial tissue in vagina)
What is the medical management of endometriosis?
1) NSAIDs and paracetamol for pain
2) GNrH antagonists (creates early menopause)
What is the surgical management of endometriosis?
- Want kids: scraping off
- Don’t: hysterectomy
What is the prognosis for endometriosis?
- Gets better post-menopause
- Chronic for 2/3
- Spontaneous remission for 1/3
Adenomyosis?
- Endometrial tissue in the myometrium
- Common for multiparous women towards end of reproductive years
- Enlarged boggy uterus
- Dysmenorrhoea and menorrhagia
- GnRH agonist + hysterectomy
Epidemiology of PID?
- Common below 25
- Chlamydia most common cause
- Presents similarly to endometriosis but in younger women
Risk factors for PID?
Same as STI + copper coil insertion (give prophylactic ABx)
Features of PID?
- Severe lower abdo pain and dyspareunia
- Irregular bleeding (heavy, postcoital, dysmenorrhoea)
- Offensive discharge
- Fever (infective)
- Cervical excitation
What are the investigations for PID?
- Rule out pregnancy
- Look for evidence of infection (WCC, CRP, STI)
- Transvaginal USS may show dilated tubes
What its the management of PID?
1st) 1g IM ceftriaxone stat + doxy 100mg 2ds + metronidazole 400mg 2ds for 14/7
2nd) Oral ofloxacin + oral metronidazole both 400mg BD for 14/7
What is are the complications for PID?
- 20% infertility
- Chronic pelvic pain
- Adhesions
- Ectopic
- Fitz-Hugh-Curtis syndrome (perihepatic irritation; RUQ pain)