Womans Health Flashcards
Menorrhagia
Heavy cyclical bleeding
Polymenorrhoea
Normal duration and flow but shortened cycle with intervals less than 25 days
Metorrhagia
Uterine bleeding independent of menstrual pattern
Menometorrhagia
Increased flow during menstruation and between periods
Chronic AUB
More than 6 months
Acute AUB
Severe enough to require immediate intervention
HMB
Heavy menstrual bleeding that affects quality of life
Objective Menorrhagia (HMB)
- blood loss > 80ml per cycle
- 60% have iron deficiency anaemia
Subjective Menorrhagia
50% have bold loss in normal limits
Still considered abnormal
Normal blood loss
10-55 ml
Causes of AUB
- polyps
- adenomyosis
- leiomyomas
- malignancy
- coagulopathy
- ovulation dysfunction
- endometrial disorders
- iatrogenic
- not classified
Types of leiomyomas
- sub mucosal
- other (intramural and sub serosal)
- hybrid
Feature of coagulopathy
One of: - postpartum haemorrhage - surgical related bleeding - dental bleeding Two or more of: - bruising - epistaxis - frequent gum bleeding - fam history of bleeding symptoms
What are LOOP events?
- luteal out of phase events
Premature development of estradiol-producing follicles in the luteal phase
Things causing endometrial disorders
- deficiencies in the local production of vasoconstrictors (endothelin1)
- increased prod of vasodilatory prostaglandins (prostacyclin)
- accelerated lysis of endometrial clot (plasminogen activator)
Things causing iatrogenic AUB
- break through bleed
- mirena
What is used for endometrial sampling?
Pipelle
Who do you take an endometrial sample from?
- over 40’with irreg bleeding
- risk factors for endometrial Ca
Prolonged chronic anovulatin
Obese
Fam Hx of Ca
Who do you refer for hysteroscopy?
- chronic irreg bleeding
- peri-menopause with abnormal bleeding
- US suggests fibroid or polyp
- post- menopause ET >5mm or ongoing bleeding with ET <5 mm
How to hormonally manage an acute bleeding episode
- high dose oestrogen for atrophic endometrium
- high dose OCP if bleeding not too severe
- progesterone for anovulatory bleeding
- cyclokapron (antifibrinolytic)
Medical management of AUB
- antifibrinolytic drugs (tranexamic acid)
- NSAIDS (mefenamic acid)
- low dose Monophasic oral contraceptives
- progesterone
- mirena
Mechanism of tranexamic acid
Prevents action so plasminogen
Mechanism of mefenamic acid
Altered ratio of prostaglandin E2 to F2
- increased ratio of prostacyclin to thromboxane
Mirena method of action
- reduction in endometrial prostaglandin synthesis
- reduction in endometrial fibrinolytic activity
- production of an inactive endometrium
When is endometrial ablation done
- HMB with uterus <3 cm and no desired fertility
Types of endometrial ablation
First gen - electrocautery Second gen - microwave endometrial ablation - hydrothermablation
What does UAE stand for?
Uterine artery embolisation
When is UAE, myomectomy or hysterectomy done?
HMB with fibroids >3 cm
When is hysterectomy done?
- completed family
- over 45
- fAiled medical treatment
- failed endometrial ablation
- failed myomectomy
What is a haematinic?
Stimulates the production of red blood cells
AUB-O
Abnormal menstrual bleeding with a disorder of ovulation (endometrial sampling NB- assoc with endometrial hyperplasia)
When is normal vag discharge least acidic?
Days prior to and during menstruation
Physiological causes of changes in discharge
- menstrual cycle
- emotional stressors
- nutritional status
- pregnancy
- medications
- sexual arousal
Trichomoniasis discharge
Yellow/green, offensive, frothy