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Celiac disease
Autoimmune reaction to wheat, barley, and rye
1) Genetically predisposed
2) self-destructive immune response when gliadin penetrates intestinal lining and sets off inflammatory cells in tissue
No celiac gluten sensitivity (NCGS)
Other components can be cause of reaction:
Proteins in wheat, barley, rye
1) amylase, trypsin inhibitors
(very possibly psychosomatic) ‘Immune reaction to gluten or another substance in wheat’ [antibodies to gliadin]
Has no biological markers
Based on self reported symptoms “gluten challenge”
Imbalance in gut microbes = intestine more permeable
Antibodies against gluten :: Barrier on intestines might be defective (partially digested gluten to get out of gut and interact w/ immune cells in blood) or immune response-provoking bacteria –> make way to bloodstream and liver cause inflammation
Excess of Poorly absorbed carbohydrates
Irritable bowel syndrome: Abdominal pain, bloating, and gas
Wheat allergies
Release immunoglobulin E antibodies against wheat proteins
1) vomiting
2) itching
3) shortness of breath
Fructants
Carbs in wheat’ can account for as much as half of a person’s FODMAPS intake
FODMAPS
fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Can cause bloating when fermented in the gut
Symptoms of irritable bowel syndrome
Noveno effect
Mère expectation kg swallowing dreaded ingredients worsen symptoms
Lyndon FODMAPS
-did not recruit people from ‘gluten challenge’ “didn’t include people with true wheat sensitivity”
–no reports of rash or fatigue to point widespread immune condition
Aladdin’s wheat
- No blinded challenge
- nocebo effect