O.D.C.A

Question 1

NLRP3

Answer 1

Inflammasome
Hypersensitive protein
Inflammation it triggers hurst more than helps
Sensor protein in inflammasome
Detects sterile danger signals
Lacks. Natural ligand
Lacks obvious binding pocket drug can attach 
Cryopyrin

Question 2

MCC950

Answer 2

Selective NLRP3 inhibitor
highly specific NLRP3 inhibitor with nanomolar potency
Best compound that blocked nlrp3 protein complex
Tested in 80 animal models for 50< diseases
Renamed from CRID3

Question 3

Statins

Answer 3

Pills taken daily by 40million americans to lower cholesterol

Question 4

NLRP3 inhibitors

Answer 4

May help ward off alzheimer’s, cancer, fatty liver disease, other alignments linked to chronic inflammation

Binds near a region important to for atp hydrolysis

Question 5

IL-1beta

Answer 5

Cytokine
Promotes inflammation
Activated by inflammasomes

Question 6

Inflammasomes

Answer 6

Security systems that prompt cells to self-destruct

All have an adapter protein called ASC, enzyme caspase-1, rotating cast of sensory proteins (detect viral intruders)

Question 7

Sterile danger signals

Answer 7

Toxins that build up in our body from old age

Question 8

Glyburide

Answer 8

Diabetes drug, blocks IL-1beta release
Fro. It CRIDs where created
Blocked IL-1beta release because it was an NLRP3 inhibitor (weak one)

Question 9

CRIDs

Answer 9

Cytokine release inhibitory drugs
Diarylsulfonylurea compounds
Higher doses of it causes liver damage

Question 10

Gout

Answer 10

Inflammation caused by monosodium urate and calcium pyrophosphate dihydrate crystals that activate NLRP3 inflammasome

Question 11

IL-1BETA BLOCKERS

Answer 11

canakinumab

Can cause infections

Question 12

Gasdermin-D

Answer 12

Downstream protein prompts dramatic cellular explosion after inflammation activation
Pyroptosis