F.I.B Flashcards
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Bispecific antibodies
Off-the-shelf given intravenously
Molecular rope (antibody) tethered her natural t-cells to the tumor cells
Can be made produced in advance
Can be good for blood and lymph cancers
Might work equally well in (myeloma-blood cancer)
Challenging to design and produce-however now faster, more potent and safer
Often does not give the same omg. Lasting remissions as CAR T
Not that good with solid tumors (colon & lungs(
CAR T cells
Chimeric antigen receptor t-cells
Harvesting patients blood, engineering them to have receptors for tumor antigen, growing more, infusing back in
Takes too long, has to be prepared for each cancer patient
Altered to carry a receptor that targets a cancer cell antigen
Antibodies
Y showed proteins, binding takes place at tips of Y
Can directly disable, and clear a pathogen or can signal immune response to it
Modular, w/ two identical heavy chains(stem/half of each arm), 2 identical light chain(each completed one arm)
Pathogen fighters, latch onto antigen on viruses bacteria, microbes
Monoclonal antibodies
Trastuzumab/herceptin–(breast cancer drug)
Checkpoint inhibitor
Drugs that release the molecular brakes that can restrain T cells, can also boos the T cells attack
T cell CD3 protein
If this is used the all T cells can engage directly attack not just the trained ones
Cytokine storms
Immune overreaction in which white blood cells pump out signals called cytokines that can be toxic in large quantities
Can be caused by both CAR T and bispecifics
BiTE
Bispecific T cell engager
Pump
Stripped down bispecific antibody with two tips linked by a flexible peptide instead of traditional stem
Similar to CAR T- release toxic molecules and performs that punch holes in tumor cells and cause self destruct