wk8 principles of pahrmacokinetics Flashcards
1
Q
first order kinetics
A
when the rate of drug elimination is proportional to drug concentration. meaning a constant fraction of the drug is eliminated.
2
Q
xero order kinetics
A
metabolism/excretion is independent of plasma drug concentration.
3
Q
bioavailability
A
fraction of drug that reaches systemic circulation unchanged
4
Q
volume of distribution
A
how extensively the drug is distributed. small vd means drug is confined to bloodstream while large vd means drug highly distributed throughout the body.
= amount of drug / plasma conc
5
Q
clearance
A
= elimination rate / plasma conc
6
Q
steady state conc
A
when rate of drug adminsitration equals elimination.
= dose rate/ CL
7
Q
maintenance dose
A
after css is achieved, the dose rreuired to keep conc within therapeutic range
= CL / css
