wk 5 drug absorption and distribution

Question 1

most common mechanism of transport

Answer 1

passive diffusion by conc gradient. drugs move from area of high conc to low conc. applies to lipid soluble drugs

Question 2

mechanism of transport thats reliant on energy

Answer 2

active transport - needs atp. often happens in organs like liver, kidney against conc gradient

Question 3

endocytosis

Answer 3

used to transport large molecules like proteins/drugs. cell membrane engulf the drug, forming a vesicle thats ttransported to the cell

Question 4

filtration

Answer 4

passage of water soluble drugs through pores in capillary

Question 5

patients factors that affect absorption

Answer 5

• stomach emptying rate
• intestinal motility
• intreraction with food

Question 6

how does tissue uptake distribution work

Answer 6

its dependant on blood flow. drugs that receive more blood receive more drug (for example brain, liver, kidney receive lot while muscle, skin, fat receive less)

Question 7

what is special about the brain blood barrier (BBB)

Answer 7

only lipid-soluble drugs can pass through BBB because the endothelial cells in the brian are tightly packed to only allow certain molecules through

Question 8

problem with protein binding

Answer 8

drugs bind to plamsa proteins like albumin, limiting their availability to tissues. only unbound or free drugs can exert pharmacological effect.