case study 2

Question 1

What are the potential implications of Brown’s history of myocardial infarction (heart attack) for his current symptoms?

Answer 1

his past history indicates that he might be having another heart attack which is why the gtn spray is not helping

Question 2

Why did the doctor choose to administer soluble aspirin instead of the enteric-coated slow-release form in this emergency situation?

Answer 2

because it can deliver the therapeutic effect quickly. compared to this, the slow-release is designed to bypass the stomach and release the drug in small intestine for prolonged effect

Question 3

What is the primary mechanism of action of metoprolol

Answer 3

Metoprolol is a beta-1 antagonist. Beta 1 receptors are mainly located in the heart. By blocking these, metoprolol reduces heart rate, contractility, blood pressure, and oxygen demand. This helps manage hypertension/angina.

Question 4

What is the primary mechanism of action of aspirin

Answer 4

Aspirin irreversibly inhibits the enzyme cyclooxygenase (COX-1). This inhibition leads to a decrease in the production of thromboxane A2, a substance that promotes platelet aggregation and vasoconstriction.

Question 5

What is the mechanism of GTN

Answer 5

GTN converts to nitric oxide in the body. NO then activates guanylate cyclase, which increases cyclic GMP. veins are dilated to reduce venous return to the heart. since heart workload is reduced, oxygen demand is reduced as well.