Wk.4 L4 - Calorie Restriction

Question 1

LO

Answer 1

• Outline different diets that can mediate calorie restriction
• Explain important caveats of calorie restriction studies in model organisms
• Outline some of the published effects of calorie restriction on longevity in animal models

Question 2

Impact of Dietary Restriction on aging-associated dissorders

Answer 2

Dietary interventions:
- Ad Libidum (free access)
- Intermittent fasting (Fast every other day)
- Calorie Restiction (50% less food)
- Time restricted feeding (9am-3pm feeding)
- Macronutrient ratio changes (zero carbs)

Question 3

Calorie Restriction Studies

Answer 3

Most popular studied:
- Calorie Restriction (1980s started research)
- Intermittent fasting (2000s started research)

Animal models:
- Calorie restriction on rats found it extented their lifespan
- Ad Libidum always had food availible
- Cal. Restricted was given all food at one time
This can be argued to beintermittent fasting as they fast 50% of the time as well as 50% less calorie intake

Question 4

Good evidence in non-human primates

Answer 4

• Clostest to humans in lifespan extension
• Calorie restriction extended their lifespan significantly by checking on age-related diseases

Question 5

Fasting Mimicking Diet

Answer 5

Extends healthspan in mice
- Similar to intermittent fasting
- Statistically significant evidence to age-related diseases being lower and longer lifespans

Question 6

Calorie Restriction benefits

Answer 6

• Neurodegenetive diseases
• Cancers
• CVD
• Excess adiposity and diabetes
• Kidney disease
• Autoimmune disease and inflammation

All decreasing, therefore extending healthspan and lifespan