Wk 6 TBL 4 GI Infections Flashcards
Esophagitis
- inflammatory process caused by infection
- most often in immunocompromised
- extent of damage related to severity of symptoms
Causes of esophagitis
- Candida (fungal) - often in immunocompromised, HIV
- Herpesviruses
a. CMV
b. Herpes simplex virus - acid reflux
- medication-induced (doxycycline)
2 key clinical manifestations of esophagitis
- odynophagia (pain on swallowing)
- dysphagia (difficulty swallowing)
Dx of esophagitis
empiric trial of fluconazole -> improvement -> assumed Candida esophagitis
2. endoscopy and biopsy
Gastritis
- can be erosive or nonerosive
Define peptic ulcer disease
break in the gastric and adjacent duodenal mucosa
What causes peptic ulcer disease
Helicobacter pylori
Clinical presentation of gastritis
- dyspepsia (epigastric pain, burning)
- n/v
- can be asymptomatic
Pathogens associated w/ gastritis
- H. pylori
- CMV
- Histoplasma capsulatum (fungi)
- Mucor (fungi)
- Anisakis (larvae after raw fish)
- Mycobacteria (TB and nonTB)
- Giardia
- STronglyoides
- EtOH
- meds (NSAIDS)
Dx gastritis
endoscopy w/ gastric biopsy
H. pylori confirmed w/ urease test or urea breath test or stool antigen test
Tx of H. pylori gastritis
Quad therapy:
1. tetracycline
2. bismuth
3. metronidazole (or tinidazole)
4. PPI (omeprazole)
OR:
1. amoxicillin
2. clarithromycin
3. metronidazole (or tinidazole)
4. PPI
Other names for diarrhea
Define acute and chronic
= gastoenteritis, enterocolotis
-Either acute (<2 wks) or chronic (>4 wks)
What are 2 categories of acute diarrhea?
- noninflammatory (watery, nonbloody)
- inflammatory (bloody w/ pus) = dysentery
4 Characteristics of watery diarrhea
- No RBCs or WBCs in stool
- typically afebrile
- usually large-volume
- infection typically sm intestine
4 char of dysentery
- RBC and WBC in stool
- often febrile
- usually small volume
- infection typically colon
9 organisms that cause watery diarrhea
- ETEC
- Vibrio cholerae
- Staph aureus
- Bacillus cereus
- Listeria monocytogenes
- Norovirus
- Rotavirus
- Giardia lamblia
- Cryptosporidium hominis