Wk 28 - CNS + MSK OTC Flashcards
Give examples of types of headaches
- Migraine
- Tension headache
- Sinusitis
- Cluster headaches
- Temporal arteritis
- Trigeminal neuralgia
- Chronic daily headache
- Medication overuse
What is a migraine?
- Complex neurological condition
- Severe/moderate headache
- Throbbing + pulsating
What are the key feature that support the diagnosis of migraines?
- Nausea + vomiting
- Photophobia
- Phonophobia
- Disability
What are the causes of a migraine?
Vasodilation of blood vessels in brain
Outline the main classifications of migraines
- Migraine w/ aura
- Migraine w/o aura
- Chronic migraine
- Menstrual migraine
Give examples of migraine w/ aura
- Typical aura
- Hemiplegic migraine
- Migraine w/ brainstem aura
- Ocular
- Silent
Outline the features of migraine w/o aura
- Recurrent headache
- Attacks last 4-72 hrs
- Unilateral, pulsating, mod/severe
- Aggravated by physical activity
- Association w/ nausea, vom, photophobia + phonophobia
- Relief from lying in darkened room
- No neurological symptoms
Outline the features of migraine w/ aura
- Transient, unilateral
- Visual, sensory + other CNS symptoms that develop gradually
- Occurs 5-20 mins before headache
- Prodromal + post-dromal phases occur
- Neurological symptoms precede headache
- More common in women
Visual aura
- Flashing lights
- Scotoma
- Zigzag lines (photopsia)
Sensory aura
- Unilateral tingling or numbness in lips, fingers, face + hands
- Difficulty in speaking (dysphasia)
What is the ICHD-3 diagnostic criteria for migraine w/o aura?
- > 5 attacks fulfilling 3 criteria
- Headache lasting 4-72 hrs
2/4:
- Unilateral
- Pulsating
- Mod/severe pain
- Aggravated by physical activity
During headache at least 1 present:
- Nausea and/or vom
- Photophobia + phonophobia
What is the ICHD-3 diagnostic criteria for migraine w/ aura?
> 2 attacks fulfilling 3 criteria
1/more:
- Visual
- Sensory
- Speech
- Motor
- Brainstorm
- Retinal
At least 3:
- At least 1 aura symptom gradually over 5 mins
- 2/more aura symptoms
- Each symptom lasts 5-60 mins
- 1 unilateral
- 1 +ve
- Aura accompanied w/in 60 mins of headache
Give an example of a diet trigger for migraine
- Crash diet
- Irregular meals
- Cheese
- Chocolate
- Red wine
- Tyramine containing foods
Give an example of an environmental trigger for migraine
- Smoking
- Bright light
- Screen use
- Strong smell
Give an example of an psychological trigger for migraine
- Depression
- Anxiety
- Stress
- Anger
Give an example of medicinal triggers for migraine
- HRT
- COC
Give other examples of triggers for migraine
- Menstruation
- Shift pattern
- Menopause
Give treatment options OTC for acute migraine
- Simple analgesia
- Anti-emetic
- Migraine specific treatment: triptans or 5HT1 agonist
Give examples of simple analgesia for migraines
- Paracetamol
- Ibuprofen
- Aspirin
Use early in attack to avoid gastric stasis
Give examples of anti-emetics used for migraines
Gastric stasis slowed in migraine (red med absorption)
- Migraleve pink: codeine, paracetamol + buclizine
- Buccastem M buccal: prochlorperazine 3mg - previously diagnosed migraine + adults
How do serotonin 5-HT1 agonists or triptans work to reduce migraines?
- Imitate 5-HT
- 5-HT causes dilated blood vessels to constrict
- Included 1st line along simple analgesia + anti-emetic in mod/severe migraine
- Red pain w/in 2 hrs
- Red photophobia + phonophobia
Give examples of triptans
- Almotriptan
- Naratriptan
- Sumatriptan
- Zolmitriptan
What is the criteria to supply sumatriptan (imigran)?
- 18-65
- Migraine diagnosed by doc/pharmacist
- Established pattern of migraine w//w/o aura (5/more over year)
- Simple analgesic ineffective