Wk 2 Quiz 1 Review

Question 1

What lab method is used to detect hemoglobinopathies?

Answer 1

HPLC

Question 2

How are alpha and beta thalassemias detected?

Answer 2

alpha: genetic testing
beta: Hb electrophoresis

Question 3

What are JAKs?

Question 4

What is STAT5?

Answer 4

a transcription factor that is recruited by JAKs on RBC precursors to increase production of RBCs

Question 5

What happens to prolyl and asparagine hydroxylases in hypoxia?

Question 6

What is the mechanism of hemolytic transfusion reacions?

Question 7

What is the mechanism of allergic transfusion reacions?

Question 8

What is the mechanism of FNHTR transfusion reacions?

Question 9

What is the mechanism of TRALI transfusion reacions?

Question 10

What is the mechanism of sepsis transfusion reacions?

Question 11

What is the mechanism of TACO transfusion reacions?

Question 12

What is the mechanism of delayed hemolytic or serologic transfusion reacions?

Question 13

What are signs/symp of TTP?

Answer 13

thrombocytopenia, fever, neuro sx, ↓ADAMTS13 act. <10%