Wk 2: Cell to cell communication, cell division, genetics and inheritance Flashcards
Juxtacrine (direct) communication
contact dependent signalling
cells need to be in physical contact with each other through signalling membrane proteins
Indirect comminication
no direct contact between communicating cells
requires specific messenger molecules
What are the 5 main types of indirect cell to cell communication?
- Endocrine
- Neurocrine/neuroendocrine
- Paracrine
- Autocrine
- Neurotransmission
What types of indirect communication occur via the blood?
- Endocrine
- Neurocrine
What types of indirect communication act on nearby cells?
- Paracrine
- Autocrine
- Neurotransmission
Endocrine cell communication
Involves an endocrine cell producing a hormone (e.g adrenal gland producing cortisol) which travels through the bloodstream to reach target cell
Neuroendocrine cell communication
Involves a neuroendocrine cell (present in the brain) which produces a neurohormone (e.g oxytocin, ADH), then travelling via the blood stream to reach the target cell (e.g kidney)
Paracrine cell communication
Involves a paracrine cell which secretes/release a messenger molecule (paracrine molecule) which is then able to act on target cells which are nearby
Autocrine cell communication
Involves an autocrine cell producing an autocrine molecule. Target cells it can act on are only other autocrine cells (e.g immune cells)
Neurotransmission cell communication
Involves a neuron which produces the messenger molecule, neurotransmitter. The neurotransmitter can act on several molecule types i.e smooth muscle, gland ot another neuron
Neurosecretion
A neuro hormone is released from a neuron and travels via the bloodstream to teach the target cell
Neurotransmission
A neurotransmitter is released from the neuron and travels via the synapse to reach another neuron, gland or muscle
Hormones
essential in the human body for roles such as:
1. control growth & development
2. Metabolism & energy balance
3. Immune system response
What are the 2 types of hormones?
- Water soluble hormones
- Lipid soluble hormones
Water soluble hormones
e.g amine, insulin, glucagon
these hormones are secreted through exocytosis, travel through the blood stream, attach to a receptor on the target cell
Lipid soluble hormone
e.g steroid hormones, thyroid
Synergistic target cell response
enhance action of another hormone
e.g glucagon and adrenaline both raise blood glucose)
Antagonistic target cell response
Oppose action of another hormone
e.g glucagon raises blood glucose, insulin reduces it)
Ligand receptors
specific proteins that function when a specific molecule binds to the receptors
Gene
unit of heredity
found at a specific location on a chromosome
codes for a specific protein/enzyme to be made
Allele
alternate DNA sequence version of a gene
2 per gene on autosomes (1 from mum, 1 from dad)
Autosome
chromosome pairs 1-22 (same in males and females)_
Sex chromsome
pair 23 (XX in F, XY in M)
Mitosis
Meiosis
forms gametes
New cells=different from parent cells (creates 4 genetically different daughter cells)
2 rounds of division; 1st division halves the chromosome number
Prophase I, metaphase I, anaphase I, telophase I & cytokinesis, prophase II, metaphase II, anaphase II, telophase II & cytokinesis
Mutation
change in the DNA sequence for a gene–>new allele
can be a single nucleotide change/swap or multiple ones