WHO CLASSIFICATION OF CHRONIC MYELOGENOUS LEUKEMIA

Question 1

WHO 3 CLASSIFICATION OF CHRONIC MYELOGENOUS LEUKEMIA

Answer 1

I. Chronic phase (CML-CP )
II. Accelerated phase (CML-AP )
III. Blast phase (CML-BP )

Question 2

blood studies shows mild anemia and leukocytosis (>25x109/L)

a. (CML-CP)
b. CML-AP )
c. (CML-BP )

Answer 2

a. (CML-CP)

Question 3

2) Primarily comprising neutrophils in various stages of maturation (increased myelocytes and mature neutrophils)
3) Basophils are universally increased
4) Eosinophilia is common
5) Serum LDH and uric acid - increased

a. (CML-CP)
b. CML-AP )
c. (CML-BP )

Answer 3

a. (CML-CP)

Question 4

CHRONIC MYELOGENOUS LEUKEMIA :

Serum LDH and uric acid - increased in CHRONIC PHASE due to excessive

A. EOSINOPHIL
B. BASOPHIL
C. CELL PROLIFERATION

Answer 4

C. CELL PROLIFERATION

Question 5

increasing white count and spleen size despite therapy

a. (CML-CP)
b. CML-AP )
c. (CML-BP )

Answer 5

b. CML-AP )

Question 6

Blast accounting for more than or equal to 20% of peripheral white cells or nucleated bone marrow cells.
a. (CML-CP)
b. CML-AP )
c. (CML-BP )

Answer 6

c. (CML-BP)

Question 7

persistent thrombocytopenia (<100 x109/L)

or thrombocytosis (>1000 x 109/L) despite treatment

a. (CML-CP)
b. CML-AP )
c. (CML-BP )

Answer 7

b. CML-AP )

Question 8

persistent thrombocytopenia

a. (<100 x109/L)
b. (>1000 x 109/L
c. s (>100 x 109/L

Answer 8

a. (<100 x109/L)

Question 9

Blast proliferating in extramedullary site (such as skin, lymph node, spleen

a. (CML-CP)
b. CML-AP )
c. (CML-BP )

Answer 9

c. (CML-BP )

Question 10

thrombocytosis

a. (>1000 x 109/L)
b >100 x 109/L)

Answer 10

a. (>1000 x 109/L)

Question 11

3) blast making up 10% to 19% of bone marrow or peripheral blood white cells
4) peripheral blood basophilia of more than or equal to 20%

a. (CML-CP)
b. CML-AP )
c. (CML-BP )

Answer 11

b. CML-AP )

Question 12

Large aggregates of blasts occurring in the bone marrow.

a (CML-CP)
b. CML-AP )
c. (CML-BP )

Answer 12

c. (CML-BP )

Question 13

** WHO DIAGNOSTIC CRITERIA FOR CML :**

Persistent monocytosis in the peripheral blood

a. (> 1x109/L)
b. (< 1x109/L)

Answer 13

a. (> 1x109/L)

Question 14

GRANULOCYTES ACCOMPANY THE LEUKEMIC BLASTS (OPEN ARROWS)
WHO DIAGNOSTIC CRITERIA FOR CML:

No Philadelphia chromosome on

a. BCR/ABR fusion gene
b. BCT/ABR fusion gene

Answer 14

a. BCR/ABR fusion gene

Question 15

Mamatay na pota

Question 16

3) < 20% blasts (including myeloblasts, monoblast, or promonocyte) in the peripheral blood or bone marrow.
4) Dysplasia in one or more myeloid lines.

A. CML
B.AML

Answer 16

A. CML

Question 17

Fourth criterion may be present if bone marrow cells have an acquired clonal, cytogenetic abnormality or if unexplained monocytosis has
been present for at least 3months.

A. CML
B.AML

Answer 17

A. CML