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HEMA 2024DIZON Finals > 2) Acute myeloid leukemia with recurrent genetic abnormalities > Flashcards

2) Acute myeloid leukemia with recurrent genetic abnormalities Flashcards

1
Q

Acute myeloid leukemia with recurrent genetic abnormalities

AML with
a. t (8;21) (q22; q22)
b. t(15;17) (q22;q12)

A

a. t (8;21) (q22; q22)

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2
Q

AML with abnormal bone marrow eosinophils inv\

a.inv(16)p13q22
b. t(16;16)(p13;q22)
c. t(15;17) (q22;q12) and variants

A

a.inv(16)p13q22
b. t(16;16)(p13;q22)

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3
Q

Acute promyelocytic leukemia

a. 11q23 abnormalities
b.. t(15;17) (q22;q12) and variants

A

b.. t(15;17) (q22;q12) and variants

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4
Q

**AML with **
a. 1q23 abnormalities
b.1q24 abnormalities

A

a. 1q23 abnormalities

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5
Q

AML with t(8;21) (q22;q22)

a. 5%-10% of AML
cases
b. 10% of AML cases
c. 5% of AML
d.

A

a. 5%-10% of AML
cases

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6
Q

10% of AML cases
a. ML with inv (16) (p13q22)
b. t(16;16) (p13;q22)
c. t(15;17) (q22;q12
d. ML with 11q23 abnormalities

A

a. ML with inv (16) (p13q22)

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7
Q

5% of AMl

a. ML with inv (16) (p13q22)
b. t(16;16) (p13;q22)
c. t(15;17) (q22;q12 acute promyelocytic
leukemia
d. ML with 11q23 abnormalities

A

d. ML with 11q23 abnormalities

c. t(15;17) (q22;q12

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8
Q

predominantly
younger patients

a. AML with t(8;21) (q22;q22)
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22)
c. AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
d.AML with 11q23 abnormalities

A

a. AML with t(8;21) (q22;q22)

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9
Q

occurs at any age,but more
common among children

a. AML with t(8;21) (q22;q22)
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22)
c. AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
d.AML with 11q23 abnormalitie

A

d.AML with 11q23 abnormalitie

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10
Q

blasts – typically
large, with abundant
basophilic cytoplasm, often
with Auer rods and numerous,
sometimes very large azurophilic
granules

a. AML with t(8;21) (q22;q22)
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22)
c. AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
d.AML with 11q23 abnormalities

A

a. AML with t(8;21) (q22;q22)

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11
Q

** abnormal
promyelocytes are
present, either
hypergranular or
hypogranular
(microgranular)**

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22
c. AML with t(8;21) (q22;q22)
d.AML with 11q23 abnormalities

A

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia

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12
Q

The bone marrow
usually has elements
of both granulocytic
and monocytic
differentiation
combined with
abnormal eosinophils

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22
c. AML with t(8;21) (q22;q22)
d.AML with 11q23 abnormalities

A

b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22

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13
Q

** monocytic differentiation,
with monoblasts and
promonocytes
predominating, is the most
common morphologic
pattern**

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22
c. AML with t(8;21) (q22;q22)
d.AML with 11q23 abnormalities

A

d.AML with 11q23 abnormalities

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14
Q

M4eo in FAB
classification or
acute myelomonocytic
leukemia with
abnormal eosinophils

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22
c. AML with t(8;21) (q22;q22)
d.AML with 11q23 abnormalities

A

b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22

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15
Q

M3 or M3v in FAB classification

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22
c. AML with t(8;21) (q22;q22)
d.AML with 11q23 abnormalities

A

a.AML with t(15;17) (q22;q12)

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16
Q

patients may have gum infiltration, and DIC

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22
c. AML with t(8;21) (q22;q22)
d.AML with 11q23 abnormalities

A

d.AML with 11q23 abnormalities

17
Q

Bundles of Auer
rods are present in
most cases; the
nuclei, which may
be bilobed, are
irregular in size and
variable in shape
and maybe reniform (kidneyshaped

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22
c. AML with t(8;21) (q22;q22)
d.AML with 11q23 abnormalities

A

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia

18
Q

The abundant basophilic and sometimes vacuolated
cytoplasm may form
pseudopods and contain
scattered, fine azurophilic
granules

a.AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia
b. AML with inv (16) (p13q22) or
t(16;16) (p13;q22
c. AML with t(8;21) (q22;q22)
d.AML with 11q23 abnormalities

A

d.AML with 11q23 abnormalities

HEMA 2024DIZON Finals (13 decks)

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