White Cells Online Module Flashcards
What is the life span of a neutrophil?
6-10 hours
What is the role of a neutrophil?
Phagocytosis
Chemoattraction
Utilise complement system and immunoglobulin system
What does the presence of immature neutrophils (myelocytes) suggest?
Bone marrow stress
Damage to marrow architecture to allow them to exit the marrow prematurely
LEFT shift on a blood film
Are all neutrophils in the circulation circulating?
No; a proportion will adhere to vessel walls in a reversible attachment process using adhesion molecules
Is the marginating pool of neutrophils measured on a blood count?
No
Why will steroids result in a neutrophilia?
Reduce the process of margination and so therefore there is a pseudo neutrophilia as more are circulating
What can cause a neutrophilia?
Inflammation Acute haemorrhage Neoplasia Tissue necrosis Bacterial infections; esp pygenic
What can cause an eosinophilia?
Asthma Helminthic infection Severe eczema Allergic reactions Hodgkin's lymphoma, T cell lymphomas Pulmonary syndrome; eGPA
What can cause a basophilia?
Polycythaemia rubra vera
Chronic myeloid leukaemia
Can you see the nucleus in basophila?
Tends to be obscured by dense blue/ black granules
Rich in histamine and heparin
What can cause increased serum levels of mast cell tryptase?
Systemic mastocytosis (malignant proliferation of mast cells) Recent anaphylactic reaction
What can cause a monocytosis?
Chronic bacterial infection
Malignancy; CML
Connective tissue disease; SLE and RA
For how long will monocytes circulate?
1-2 days
Where will lymphocytes arise and develop?
Arise; bone marrow
Develop in primary lymphoid organs; bone marrow and thymus
Immune responses occur in secondary lymphoid organs (lymph node, spleen, mucosal lymphoid of gut and resp tract)
What can cause a lymphocytosis?
Response to infection
Malignancy
Hyposplenism
