Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Haematology > Approach to investigation of lymphadenopathy and diagnosing lymphoma > Flashcards

Approach to investigation of lymphadenopathy and diagnosing lymphoma Flashcards

1
Q

What can cause lymphadenopathy?

A

Lymphoma
Infection; viral (regional) or bacteria (generalised)
Metastatic cancer; breast, ovarian
Connective tissue dx; sarcoid, SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What can cause night sweats?

A

Lymphoma
infection
Menopause
Too thick a duvet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What can cause wt loss with lymphadenopathy?

A

Lymphoma
Other malignancy
Infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are some specific symptoms of lymphoma?

A

Itch without rash
Alcohol induced pain
Fatigue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Describe the lymphadenopathy in a viral infection

A 
Tender
Hard
Smooth 
No skin inflammation 
Not tethered
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Describe the lymphadenopathy seen in a bacterial infection

A 
Tender
HArd
Smooth 
Skin inflamed
Yes/no to tethered to skin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Describe the lymphadenopathy seen in lymphoma

A 
Not tender
Rubbery/ soft 
Smooth surface
No skin inflammation 
Not tethered to skin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Describe the lymphadenopathy seen in metastatic disease

A 
Not tender
Hard
Irregular surface
No skin inflammation 
Tethered to skin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What should occur if lymphoma is suspected?

A

Biopsy

FNA or core biopsy is often insufficient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How is lymph node pathology assessed?

A 
Histoloy; microscopic appearances
Immunohistochemistry solid node
Immunophenotyping blood/ marrow
Genetic analysis
Molecular analysis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the purpose of immunohistochemistry?

A

Confirming it is a lymphoma
Helps to subclassify
Looks at patterns of proteins on surface of lymphoma cells
Uses antibodies against these, and enzyme reaction
Brown = positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What can be seen on histology of hodgkin’s disease?

A

Nodular sclerosing lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What CD can be seen in follicular NHL?

A

CD20 +ve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What CD can be seen in hodgkin’s disease?

A

CD30 +ve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is immunophenotyping?

A

Cells tagged with antibodies attached to a flurochrome-emits a specific colour of light when a laser is shone on it
Determines patter of CD numbers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

For what conditions is immunophenotyping useful for?

A

Leukaemia

Lymphoma involving marrow e.g. burkitt’s lymphoma

17
Q

What is the purpose of cytogenetic analysis?

A

Specific patterns of chromosome abnormality in certain lymphomas
G banding; aspirate node, grow cells in culture and look at spread of chromsoomes

18
Q

What is pathognomonic of hodgkin’s disease?

A

Reed Sternberg CElls - very abnormal B cells which have lost normal proteins assoc with B cells e.g. CD 20

19
Q

What are the different types of lymphoma?

A

Hodgkin’s
T cell NHL
B cell non-hodgkin’s; low grade B cell or high grade B cell

Haematology (31 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions