White blood cells and Immunity Lecture slides Flashcards

1
Q

Name the two primary lymphoid organs

A

Thymus and Bone marrow

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2
Q

Name the secondary lymphoid organs

A

We have the Mucosa-associated lymphoid tissue(MALT) which includes:
Naso-pharyngeal lymph nodes.
Tonsillar lymph nodes
Bronchiolar lymph nodes
We have the Peripheral lymph nodes and Spleen
We have Gut-associated lymph nodes which include the payer’s patches

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3
Q

True or false.
Leucocytes are formed and stored in a bone marrow until needed.

A

True

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4
Q

True or false
Lymphocytes are stored in lymphoid tissue and few enters circulation.

A

True

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5
Q

Phagocytosis depends on 3 selective procedures.
Name those three procedures

A

smooth surfaces - surface rough likely to be phagocytosis.
Protective protein coats that repel the phagocytes.
Antibodies then adhere to the bacterial membranes increase susceptibility to phagocytosis.

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6
Q

Which cells forms antibodies

A

specialized White Blood Cells. B cells

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7
Q

the function and protective regulation of leucocytes.
List three

A

Phagocytosis
Forming antibodies
Activates lymphocytes to destroy or inactivates invaders

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8
Q

The inflammation is characterized by certain processes. List the characteristics of inflammation

A

Vasodilation
Capillary permeability increase
Clotting substance e.g. fibrinogen leak into interstitial spaces.
Granulocytes and monocytes migrate to the injury site in large numbers.
Swelling of the tissue cells

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9
Q

List the characteristics of Eosinophils and their function and concentration in the WBCs.

A

Weak phagocytes
Chemotactic
2% of total leucocytes
Love parasites <3
Allergies: Basophils and Mast cells attract eosinophils

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10
Q

The Parasites are large to be phagocytized, so what does the Eosinophils do.

A

eosinophils are believed to detoxify some of the inflammation-inducing substances released by the mast cells and basophils and probably also phagocytize and destroy allergen-antibody complexes, thus preventing excess spread of the local inflammatory process

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11
Q

Name the granulocytes that are hydrolytic enzymes, highly reactive on oxygen species and major basic protein.

A

Eosinophils

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12
Q

What does the basophils release to prevent coagulation.

A

Heparin

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13
Q

IgE has affinity for which cells.

A

Basophils and mast cells

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14
Q

what are pro-inflammatory

A

Basophils

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15
Q

what is inflammation?

A

Inflammation is a response of vascularized tissues to antigen or tissue damage that brings immune cells and molecules of host defence from the circulation to the tissue where they are needed to destroy the antigen

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16
Q

Name and explain the steps of inflammation.

A
  1. Recognition- antigen is recognized by the host cell.
  2. Recruitment- leucocytes and plasma cells
  3. Activation- antigen destruction begins
  4. Inflammation- control inflammation to prevent host damage
  5. Repair- damage tissue repair or cleared
17
Q

name the 1st, 2nd, 3rd line of defense under macrophages and neutrophils

A

1st line defence: Tissue macrophages
2nd line: Neutrophils
3rd line: 2nd wave macrophages

18
Q

True or false
Inflamed tissues release inflammatory cytokines (e.g. TNF and IL-10) and other substances to attracts macrophages to the inflamed site by.

A

False
inflamed tissues release inflammatory ctokines (e.g. TNF and IL-10) and other substances to attracts neutrophil to the inflamed site by.

19
Q

Explain how the neutrophils responds based on inflammation

A

↑ adhesion molecules: selectins and intercellular adhesion molecule-1 (ICAM-1) on endothelial cells surface.
React with neutrophils, stick to the endothelial cells forming the capillary and venule walls in the inflamed site.
Intercellular space between the endothelial cells
Neutrophils squeeze through the capillaries by diapedesis into the tissue spaces.
Chemotaxis of the neutrophils toward the injured tissues

20
Q

The uncontrolled production if leucocytes or abnormal production of WBCs.

A

Luekemia

21
Q

Causes of leukemia

A

Causes: mutations of myelogenous or lymphogenous cells

22
Q

differentiates between myelogenous and lymphogenous formation of leukemia

A

Lymphocytic: begin in lymph nodes or lymphatic tissue, spread to other areas
Myelogenous: cancerous production of young myelogenous cells in the bone marrow; WBCs are produced in extramedullary tissue

23
Q

what is acute

A

Acute: very undifferentiated cells

24
Q

Name 4 types of leukemia

A

Acute lymphoblastic leukemia
Acute myeloid leukemia
Chronic lymphocytic leukemia
Chronic myeloid leukemia

25
Q

What happened in myelogenous leukemia

A

In myelogenous leukemia, the cancerous process occasionally produces partially differentiated cells, resulting in what might be calledneutrophilic leukemia, eosinophilic leukemia, basophilic leukemia,ormonocytic leukemia. More frequently, however, the leukemia cells are bizarre and undifferentiated and not identical to any of the normal WBCs.

26
Q

Leukemia is characterized by what?

A

leukemia is usually characterized by greatly increased numbers of abnormal WBCs in the circulating blood.
extramedullary tissues—especially in the lymph nodes, spleen, and liver

27
Q

List six effects of leukemia in the body

A

Metastatic growth of leukemic cells in other areas of the body
Bone marrow compromise surrounding bone
Almost all eventually spread to spleen, lymph nodes, liver and other vascular regions
Thrombocytopaenia – lack of platelets, severe bleeding
Severe anaemia
Metabolic starvation – deterioration of normal tissue

28
Q

what does the leukemic tissue do?

A

The leukemic tissues reproduce new cells so rapidly that tremendous demands are made on the body reserves for foodstuffs, specific amino acids, and vitamins. Consequently, the energy of the patient is greatly depleted, and excessive utilization of amino acids by leukemic cells causes especially rapid deterioration of the normal protein tissues of the body

29
Q

what is leukopenia?

A

Bone marrow produces very few WBCs  compromised immunity

30
Q

what causes of leukopenia?

A

Exposure of the body to x-rays and gamma rays
Exposure to substances containing benzene or anthracene nuclei cause aplasia (reduce WBC production) of the bone marrow
Drugs such as chloramphenicol (an antibiotic)and thiouracil used to treat thyrotoxicosis.

31
Q

symptoms of leukopenia

A

Normal microbiome is balanced
Ulcers in mouth and colon, bacteria invade other tissue