White blood cells

Question 1

Outline mast cells

Answer 1

Located in tissues only, release substances that affect vascular permeability, prominent in mucosal and epithelial tissue.

Question 2

Outline basophils

Answer 2

They bind IgE, involved in allergic responses, nonphagocytic cells and they have a lobed nucleus and have a heavily granulated cytoplasm.

Question 3

Outline Eosinophils

Answer 3

Bilobed nuclei and granulated cytoplasm thought to play a role against parasitic organisms

Question 4

What are cytokines

Answer 4

Messenger molecules which are primarily secreted by WBC’s, also assist in regulating the development of immune effector cells

Question 5

What are chemokines

Answer 5

They are a type of cytokine that induces directed chemotaxis in local responsive cells.

function mainly as attractants for leukocytes, MCP1

Question 6

What are the two types of contact between endothelium and circulating cells

Answer 6

initial contact: p selectin and E-selectin on endothelium recognized by oligosaccharides on leukocytes

tighter adhesion: intercellular adhesion molecules on the endothelium molecules on the endothelium recognized integrins on leukocytes.

Question 7

State 3 pattern recognition receptors

Answer 7

Macrophage mannose receptor
scavenger receptor- recognizes oxidized LDL
TLR- recognizes a range of ligands