Bleeding disorders

Question 1

What are some causes of bleeding disorders

Answer 1

Vascular disorders
platelet disorders: thrombocytopenia, defective function.
defective coagulation

Question 2

What are the causes of vascular bleeds

Answer 2

problems with the vessel wall may be inherited or acquired: scurvy or steroids

Question 3

What is haemophillia A due to

Answer 3

A deficiency of factor VIII

Question 4

What is haemophillia B due to

Answer 4

A deficiency of factor IX

Question 5

What does APTT assess

Answer 5

activated partial thromboplastin time: assesses the intrinsic pathway

Question 6

What does PT assess

Answer 6

prothrombin time: assesses the extrinsic pathway

Question 7

What are some other tests of coagulation

Answer 7

TT, fibrinogen level, factor level assay and bleeding time

Question 8

What are some anti-coagulant drugs

Answer 8

latrogenic: heparin & warfarin
DOAC’s: direct thrombin inhibitors: dabigatran
factor Xa inhibitors: rivaroxaban

Question 9

What factors are involved in the extrinsic pathway

Answer 9

factors 2,5,7&10